Nanoparticle-Based Therapeutics for Brain Injury

Vimala N. Bharadwaj, Duong T. Nguyen, Vikram Kodibagkar, Sarah Stabenfeldt

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Brain injuries affect a large patient population with major physical and emotional suffering for patients and their relatives; at a significant cost to the society. Effective diagnostic and therapeutic options available for brain injuries are limited by the complex brain injury pathology involving blood–brain barrier (BBB). Brain injuries, including ischemic stroke and brain trauma, initiate BBB opening for a short period of time, which is followed by a second reopening for an extended time. The leaky BBB and/or the alterations in the receptor expression on BBB may provide opportunities for therapeutic delivery via nanoparticles (NPs). The approaches for therapeutic interventions via NP delivery are aimed at salvaging the pericontusional/penumbra area for possible neuroprotection and neurovascular unit preservation. The focus of this progress report is to provide a survey of NP strategies employed in cerebral ischemia and brain trauma and finally provide insights for improved NP-based diagnostic/treatment approaches.

Original languageEnglish (US)
Article number1700668
JournalAdvanced Healthcare Materials
Volume7
Issue number1
DOIs
StatePublished - Jan 10 2018

Keywords

  • blood–brain barrier
  • cerebral ischemia
  • nanoparticles
  • therapeutic nanoparticle delivery
  • traumatic brain injury

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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