Nanoparticle-based sensing of glycan-lectin interactions

Zong Dai, Abdel Nasser Kawde, Yun Xiang, Jeffrey LaBelle, Jared Gerlach, Veer P. Bhavanandan, Lokesh Joshi, Joseph Wang

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Here we present the first report on nanoparticle-based biosensing of glycan markers of diseases. The protocol relies on the competition between a nanocrystal (CdS)-tagged sugar and the target sugar for the binding sites of surface-confined lectin and monitoring the extent of competition through highly sensitive electrochemical detection of the captured nanocrystal. This development is expected to allow decentralized detection of carbohydrate moieties and lectin-carbohydrate interactions to be performed more rapidly, sensitively, inexpensively, and reliably.

Original languageEnglish (US)
Pages (from-to)10018-10019
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number31
DOIs
StatePublished - Aug 9 2006

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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  • Cite this

    Dai, Z., Kawde, A. N., Xiang, Y., LaBelle, J., Gerlach, J., Bhavanandan, V. P., Joshi, L., & Wang, J. (2006). Nanoparticle-based sensing of glycan-lectin interactions. Journal of the American Chemical Society, 128(31), 10018-10019. https://doi.org/10.1021/ja063565p