Nanoengineered biomaterials for cardiac regeneration

Lucas Karperien, Ali Navaei, Brent Godau, Alireza Dolatshahi-Pirouz, Mohsen Akbari, Mehdi Nikkhah

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Cardiovascular diseases are among the most prevalent causes of morbidity and mortality around the world. With the current crises in the shortage of donors, there is an unmet demand for developing new regenerative strategies for treatment of this life-threatening disease. Tissue engineering by combining nanoengineered materials and stem cell technologies has recently emerged as a promising approach to regenerative medicine. Biomaterials are used for the delivery of cells and drugs to repair dysfunctional myocardium. Recently, various nanoengineered approaches have been used to develop even better scaffolding biomaterials for repair and regeneration of damaged (i.e., infarcted) myocardium. In this chapter, we first introduce the structure of the myocardium by discussing its anatomy, cellular composition, and the constituents of its extracellular matrix (ECM). Then we move on to highlight a number of promising nanoengineered biomaterials for cardiac tissue regeneration with special emphasis on using multifunctional nanomaterials to nanoreinforce scaffolds. Lastly, nanopatterned substrates and their applications in cardiac regeneration are also explored.

Original languageEnglish (US)
Title of host publicationNanoengineered Biomaterials for Regenerative Medicine
PublisherElsevier
Pages95-124
Number of pages30
ISBN (Electronic)9780128133552
ISBN (Print)9780128133569
DOIs
StatePublished - Jan 1 2018

Keywords

  • Cardiac patches
  • Cardiac spheroids
  • Cardiac tissue engineering
  • Conductive scaffolds
  • Myocardial infarction
  • Nanoparticles
  • Nanotopography

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

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