Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

Jia Liu, Sonia Wennier, Nissin Moussatche, Mary Reinhard, Richard Condit, Douglas McFadden

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The myxoma virus (MYXV) carries three tandem C7L-like host range genes (M062R, M063R, and M064R). However, despite the fact that the sequences of these three genes are similar, they possess very distinctive functions in vivo. The role of M064 in MYXV pathogenesis was investigated and compared to the roles of M062 and M063. We report that M064 is a virulence factor that contributes to MYXV pathogenesis but lacks the host range properties associated with M062 and M063.

Original languageEnglish (US)
Pages (from-to)5371-5375
Number of pages5
JournalJournal of Virology
Volume86
Issue number9
DOIs
StatePublished - May 1 2012
Externally publishedYes

Fingerprint

Myxoma virus
Poxviridae
myxomatosis
Host Specificity
host range
rabbits
Rabbits
kinetics
pathogenesis
Virulence Factors
Genes
virulence
genes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits. / Liu, Jia; Wennier, Sonia; Moussatche, Nissin; Reinhard, Mary; Condit, Richard; McFadden, Douglas.

In: Journal of Virology, Vol. 86, No. 9, 01.05.2012, p. 5371-5375.

Research output: Contribution to journalArticle

Liu, Jia ; Wennier, Sonia ; Moussatche, Nissin ; Reinhard, Mary ; Condit, Richard ; McFadden, Douglas. / Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits. In: Journal of Virology. 2012 ; Vol. 86, No. 9. pp. 5371-5375.
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