Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Joanna Jazowiecka-Rakus, Aleksander Sochanik, Aleksandra Rusin, Agata Hadryś, Wojciech Fidyk, Nancy Villa, Masmudur M. Rahman, Ewa Chmielik, Lina S. Franco, Grant McFadden

Research output: Contribution to journalArticle

Abstract

Myxoma virus construct carrying the IL-15 gene was used to treat experimental pulmonary melanoma in mice. The construct was delivered systemically by mesenchymal stem (“Trojan horse”) cells and triggered an oncolytic effect and antitumor adaptive immune response. This led to marked regression of lesions and makes increased survival possible.

Original languageEnglish (US)
Pages (from-to)335-350
Number of pages16
JournalMolecular Therapy - Oncolytics
Volume18
DOIs
StatePublished - Sep 25 2020

Keywords

  • melanoma
  • mesenchymal stem cells
  • myxoma virus
  • oncolytic virotherapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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