Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Joanna Jazowiecka-Rakus; Aleksander Sochanik; Aleksandra Rusin; Agata Hadryś; Wojciech Fidyk; Nancy Villa; Masmudur M. Rahman; Ewa Chmielik; Lina S. Franco; Grant McFadden

doi:10.1016/j.omto.2020.07.003

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Joanna Jazowiecka-Rakus, Aleksander Sochanik, Aleksandra Rusin, Agata Hadryś, Wojciech Fidyk, Nancy Villa, Masmudur M. Rahman, Ewa Chmielik, Lina S. Franco, Grant McFadden

Biodesign: Immunotherapy, Vaccines and Virotherapy, Center for (CIVV)

Research output: Contribution to journal › Article

Abstract

Myxoma virus construct carrying the IL-15 gene was used to treat experimental pulmonary melanoma in mice. The construct was delivered systemically by mesenchymal stem (“Trojan horse”) cells and triggered an oncolytic effect and antitumor adaptive immune response. This led to marked regression of lesions and makes increased survival possible.

Original language	English (US)
Pages (from-to)	335-350
Number of pages	16
Journal	Molecular Therapy - Oncolytics
Volume	18
DOIs	https://doi.org/10.1016/j.omto.2020.07.003
State	Published - Sep 25 2020

Keywords

melanoma
mesenchymal stem cells
myxoma virus
oncolytic virotherapy

ASJC Scopus subject areas

Molecular Medicine
Oncology
Cancer Research
Pharmacology (medical)

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Jazowiecka-Rakus, J., Sochanik, A., Rusin, A., Hadryś, A., Fidyk, W., Villa, N., Rahman, M. M., Chmielik, E., Franco, L. S., & McFadden, G. (2020). Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma. Molecular Therapy - Oncolytics, 18, 335-350. https://doi.org/10.1016/j.omto.2020.07.003

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma. / Jazowiecka-Rakus, Joanna; Sochanik, Aleksander; Rusin, Aleksandra; Hadryś, Agata; Fidyk, Wojciech; Villa, Nancy; Rahman, Masmudur M.; Chmielik, Ewa; Franco, Lina S.; McFadden, Grant.

In: Molecular Therapy - Oncolytics, Vol. 18, 25.09.2020, p. 335-350.

Research output: Contribution to journal › Article

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