TY - JOUR
T1 - Myxoma virus in the European rabbit
T2 - Interactions between the virus and its susceptible host
AU - Stanford, Marianne M.
AU - Werden, Steven J.
AU - McFadden, Grant
PY - 2007/3
Y1 - 2007/3
N2 - Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host/poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.
AB - Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host/poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.
KW - Immunomodulation
KW - Myxoma virus
KW - Oryctolagus cuniculus
KW - Poxvirus
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U2 - 10.1051/vetres:2006054
DO - 10.1051/vetres:2006054
M3 - Review article
C2 - 17296158
AN - SCOPUS:34147136559
SN - 0928-4249
VL - 38
SP - 299
EP - 318
JO - Annales de Recherches Veterinaires
JF - Annales de Recherches Veterinaires
IS - 2
ER -