Myxoma virus expresses a TNF receptor homolog with two distinct functions

X. Xu, P. Nash, Douglas McFadden

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Myxoma virus, a member of the poxvirus family of DNA viruses, encodes many virulence factors to combat and evade the host immune responses. Among the virus-encoded immuno-modulators is M-T2, a tumor necrosis factor receptor (TNF-R) homologue. M-T2 is secreted as monomeric and dimeric species that bind and inhibit rabbit TNF in a species-specific manner. Deletion analysis indicates that the anti-TNF function is mediated by the first three of four cysteine rich domains (CRDs) of M-T2. In addition, the intracellular form of M-T2 has the ability to block virus-induced apoptosis in lymphocytes, and the first two CRDs appear to be sufficient for this function. Although the mechanisms for the anti-TNF and anti-apoptotic functions of M-T2 are not yet fully defined, we postulate that these dual activities of M-T2 are mediated through different functional motifs and abrogate distinct cellular responses to virus infection.

Original languageEnglish (US)
Pages (from-to)97-109
Number of pages13
JournalVirus Genes
Volume21
Issue number1-2
StatePublished - Oct 2 2000
Externally publishedYes

Fingerprint

Myxoma virus
Tumor Necrosis Factor Receptors
Cysteine
Viruses
Poxviridae
Aptitude
DNA Viruses
Virulence Factors
Virus Diseases
Lymphocytes
Apoptosis
Rabbits

Keywords

  • Apoptosis
  • Immuno-modulator
  • Myxoma virus
  • TNF receptor
  • Viroceptor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Virology

Cite this

Myxoma virus expresses a TNF receptor homolog with two distinct functions. / Xu, X.; Nash, P.; McFadden, Douglas.

In: Virus Genes, Vol. 21, No. 1-2, 02.10.2000, p. 97-109.

Research output: Contribution to journalArticle

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