(+)-Myristinin A, a naturally occurring DNA polymerase β inhibitor and potent DNA-damaging agent

David J. Maloney, Jing Zhen Deng, Shelley R. Starck, Zhijie Gao, Sidney M. Hecht

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

The first stereoselective total synthesis of the naturally occurring flavan myristinin A has been accomplished, as well as its biochemical evaluation. This synthesis verified the structural assignment and allowed for the determination of the absolute stereochemistry. Myristinin A exhibits biochemical activity both as a potent DNA-damaging agent and DNA polymerase β inhibitor. Relaxation of supercoiled plasmid DNA was observed at picomolar concentrations, in addition to inhibition of polymerase β at low micromolar concentrations.

Original languageEnglish (US)
Pages (from-to)4140-4141
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number12
DOIs
StatePublished - Mar 30 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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