(+)-Myristinin A, a naturally occurring DNA polymerase β inhibitor and potent DNA-damaging agent

David J. Maloney, Jing Zhen Deng, Shelley R. Starck, Zhijie Gao, Sidney M. Hecht

Research output: Research - peer-reviewArticle

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Abstract

The first stereoselective total synthesis of the naturally occurring flavan myristinin A has been accomplished, as well as its biochemical evaluation. This synthesis verified the structural assignment and allowed for the determination of the absolute stereochemistry. Myristinin A exhibits biochemical activity both as a potent DNA-damaging agent and DNA polymerase β inhibitor. Relaxation of supercoiled plasmid DNA was observed at picomolar concentrations, in addition to inhibition of polymerase β at low micromolar concentrations.

LanguageEnglish (US)
Pages4140-4141
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number12
DOIs
StatePublished - Mar 30 2005
Externally publishedYes

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DNA Polymerase beta
Nucleic Acid Synthesis Inhibitors
DNA
myristinin A
Superhelical DNA
Plasmids
Stereochemistry

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

(+)-Myristinin A, a naturally occurring DNA polymerase β inhibitor and potent DNA-damaging agent. / Maloney, David J.; Deng, Jing Zhen; Starck, Shelley R.; Gao, Zhijie; Hecht, Sidney M.

In: Journal of the American Chemical Society, Vol. 127, No. 12, 30.03.2005, p. 4140-4141.

Research output: Research - peer-reviewArticle

Maloney, David J. ; Deng, Jing Zhen ; Starck, Shelley R. ; Gao, Zhijie ; Hecht, Sidney M./ (+)-Myristinin A, a naturally occurring DNA polymerase β inhibitor and potent DNA-damaging agent. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 12. pp. 4140-4141
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