Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism

Vandana Malhotra, Ruchi Agrawal, Tammi R. Duncan, Deepak K. Saini, Josephine E. Clark-Curtiss

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: M. tuberculosis two-component systems converge to co-regulate gene expression during nitrate metabolism. Results: Analysis of nitrate/nitrite-responsive gene expression reveals novel interaction between NarL and DevR response regulators. Conclusion: Cooperative binding of NarL and DevR enables co-regulation of a subset of genes. Significance: The findings establish endogenous nitrite as a signal and highlight interplay between M. tuberculosis NarLS and DevRS/DosT signaling systems.

Original languageEnglish (US)
Pages (from-to)8294-8309
Number of pages16
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
StatePublished - Mar 27 2015

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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