TY - JOUR
T1 - Mutation rates as adaptations
AU - Maley, Carlo
N1 - Funding Information:
This work was supported in part by the generosity of the MIT AI Lab[ I am grateful to R[ Brooks\ H[ Westerho}\ M[ Donoghue\ P[ Goss\ K[ Rice and L[ King for their comments and support[ M[ Maley deserves special recognition for his time and e}orts to untangle the mysteries of this model[ I could not have completed the project without him[ I would also like to thank my reviewers for their helpful comments and criticisms[
PY - 1997/6/7
Y1 - 1997/6/7
N2 - In order to better understand life, it is helpful to look beyond the envelop of life as we know it. A simple model of coevolution was implemented with the addition of a gene for the mutation rate of the individual. This allowed the mutation rate itself to evolve in a lineage. The model shows that when the individuals interact in a sort of zero-sum game, the lineages maintain relatively high mutation rates. However, when individuals engage in interactions that have greater consequences for one individual in the interaction than the other, lineages tend to evolve relatively low mutation rates. This model suggests that one possible cause for differential mutation rates across genes may be the coevolutionary pressure of the various forms of interactions with other genes.
AB - In order to better understand life, it is helpful to look beyond the envelop of life as we know it. A simple model of coevolution was implemented with the addition of a gene for the mutation rate of the individual. This allowed the mutation rate itself to evolve in a lineage. The model shows that when the individuals interact in a sort of zero-sum game, the lineages maintain relatively high mutation rates. However, when individuals engage in interactions that have greater consequences for one individual in the interaction than the other, lineages tend to evolve relatively low mutation rates. This model suggests that one possible cause for differential mutation rates across genes may be the coevolutionary pressure of the various forms of interactions with other genes.
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U2 - 10.1006/jtbi.1996.0362
DO - 10.1006/jtbi.1996.0362
M3 - Article
C2 - 9219670
AN - SCOPUS:0031558026
SN - 0022-5193
VL - 186
SP - 339
EP - 348
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 3
ER -