Mutation load and the survival of small populations

Michael Lynch, W. Gabriel

Research output: Contribution to journalArticle

310 Citations (Scopus)

Abstract

Previous attempts to model the joint action of selection and mutation in finite populations have treated population size as being independent of the mutation load. However, the accumulation of deleterious mutations is expected to cause a gradual reduction in population size. Consequently, in small populations random genetic drift will progressively overpower selection making it easier to fix future mutations. This synergistic interaction ultimately leads to population extinction. The model also predicts that clonal lineages are unlikely to survive more than 104 to 105 generations, which is consistent with existing data on parthenogenetic animals. -from Authors

Original languageEnglish (US)
Pages (from-to)1725-1737
Number of pages13
JournalEvolution
Volume44
Issue number7
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

mutation
Population Density
Mutation
Population
population size
Genetic Drift
Population Genetics
genetic drift
extinction
animal
animals
Mutation Accumulation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

Cite this

Lynch, M., & Gabriel, W. (1990). Mutation load and the survival of small populations. Evolution, 44(7), 1725-1737.

Mutation load and the survival of small populations. / Lynch, Michael; Gabriel, W.

In: Evolution, Vol. 44, No. 7, 01.01.1990, p. 1725-1737.

Research output: Contribution to journalArticle

Lynch, M & Gabriel, W 1990, 'Mutation load and the survival of small populations', Evolution, vol. 44, no. 7, pp. 1725-1737.
Lynch, Michael ; Gabriel, W. / Mutation load and the survival of small populations. In: Evolution. 1990 ; Vol. 44, No. 7. pp. 1725-1737.
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