TY - GEN
T1 - Multivariate tensor-based brain anatomical surface morphometry via holomorphic one-forms
AU - Wang, Yalin
AU - Chan, Tony F.
AU - Toga, Arthur W.
AU - Thompson, Paul M.
PY - 2009
Y1 - 2009
N2 - Here we introduce multivariate tensor-based surface morphometry using holomorphic one-forms to study brain anatomy. We computed new statistics from the Riemannian metric tensors that retain the full information in the deformation tensor fields. We introduce two different holomorphic one-forms that induce different surface conformal parameterizations. We applied this framework to 3D MRI data to analyze hippocampal surface morphometry in Alzheimer's Disease (AD; 26 subjects), lateral ventricular surface morphometry in HIV/AIDS (19 subjects) and cortical surface morphometry in Williams Syndrome (WS; 80 subjects). Experimental results demonstrated that our method powerfully detected brain surface abnormalities. Multivariate statistics on the local tensors outperformed other TBM methods including analysis of the Jacobian determinant, the largest eigenvalue, or the pair of eigenvalues, of the surface Jacobian matrix.
AB - Here we introduce multivariate tensor-based surface morphometry using holomorphic one-forms to study brain anatomy. We computed new statistics from the Riemannian metric tensors that retain the full information in the deformation tensor fields. We introduce two different holomorphic one-forms that induce different surface conformal parameterizations. We applied this framework to 3D MRI data to analyze hippocampal surface morphometry in Alzheimer's Disease (AD; 26 subjects), lateral ventricular surface morphometry in HIV/AIDS (19 subjects) and cortical surface morphometry in Williams Syndrome (WS; 80 subjects). Experimental results demonstrated that our method powerfully detected brain surface abnormalities. Multivariate statistics on the local tensors outperformed other TBM methods including analysis of the Jacobian determinant, the largest eigenvalue, or the pair of eigenvalues, of the surface Jacobian matrix.
UR - http://www.scopus.com/inward/record.url?scp=77952277099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952277099&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-04268-3_42
DO - 10.1007/978-3-642-04268-3_42
M3 - Conference contribution
AN - SCOPUS:77952277099
SN - 3642042678
SN - 9783642042676
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 337
EP - 344
BT - Medical Image Computing and Computer-Assisted Intervention - MICCAI 2009 - 12th International Conference, Proceedings
T2 - 12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009
Y2 - 20 September 2009 through 24 September 2009
ER -