Multistage carcinogenesis in Barrett's esophagus

Carlo C. Maley

doi:10.1016/j.canlet.2006.03.018

Multistage carcinogenesis in Barrett's esophagus

Carlo C. Maley

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

The multistage carcinogenesis of esophageal adenocarcinoma is a process of clonal evolution within Barrett's esophagus neoplasms. The initiating event for Barrett's esophagus is unknown, but is associated with chronic gastric reflux which probably also promotes progression. Inactivation of both alleles of CDKN2A appear to be early events causing clonal expansion. Clones with TP53 inactivated expand if they have already inactivated CDKN2A. After TP53 has been inactivated, tetraploid and aneuploid clones tend to develop. The final events that lead to invasion and metastasis are unknown. Evolutionary biology provides important tools to understand clonal evolution in progression and cancer prevention.

Original language	English (US)
Pages (from-to)	22-32
Number of pages	11
Journal	Cancer Letters
Volume	245
Issue number	1-2
DOIs	https://doi.org/10.1016/j.canlet.2006.03.018
State	Published - Jan 8 2007
Externally published	Yes

Keywords

Barrett's esophagus
Cancer prevention
Carcinogenesis
Evolution

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2006.03.018

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title = "Multistage carcinogenesis in Barrett's esophagus",

abstract = "The multistage carcinogenesis of esophageal adenocarcinoma is a process of clonal evolution within Barrett's esophagus neoplasms. The initiating event for Barrett's esophagus is unknown, but is associated with chronic gastric reflux which probably also promotes progression. Inactivation of both alleles of CDKN2A appear to be early events causing clonal expansion. Clones with TP53 inactivated expand if they have already inactivated CDKN2A. After TP53 has been inactivated, tetraploid and aneuploid clones tend to develop. The final events that lead to invasion and metastasis are unknown. Evolutionary biology provides important tools to understand clonal evolution in progression and cancer prevention.",

keywords = "Barrett's esophagus, Cancer prevention, Carcinogenesis, Evolution",

author = "Maley, {Carlo C.}",

note = "Funding Information: Thanks to Brian Reid and Georg Luebeck for their helpful advice and criticism. This work was supported by the Wistar Institute, NIH grant K01 CA89267 and by funds provided by the Commonwealth Universal Research Enhancement Program, Pennsylvania Department of Health.",

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AU - Maley, Carlo C.

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N2 - The multistage carcinogenesis of esophageal adenocarcinoma is a process of clonal evolution within Barrett's esophagus neoplasms. The initiating event for Barrett's esophagus is unknown, but is associated with chronic gastric reflux which probably also promotes progression. Inactivation of both alleles of CDKN2A appear to be early events causing clonal expansion. Clones with TP53 inactivated expand if they have already inactivated CDKN2A. After TP53 has been inactivated, tetraploid and aneuploid clones tend to develop. The final events that lead to invasion and metastasis are unknown. Evolutionary biology provides important tools to understand clonal evolution in progression and cancer prevention.

AB - The multistage carcinogenesis of esophageal adenocarcinoma is a process of clonal evolution within Barrett's esophagus neoplasms. The initiating event for Barrett's esophagus is unknown, but is associated with chronic gastric reflux which probably also promotes progression. Inactivation of both alleles of CDKN2A appear to be early events causing clonal expansion. Clones with TP53 inactivated expand if they have already inactivated CDKN2A. After TP53 has been inactivated, tetraploid and aneuploid clones tend to develop. The final events that lead to invasion and metastasis are unknown. Evolutionary biology provides important tools to understand clonal evolution in progression and cancer prevention.

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KW - Cancer prevention

KW - Carcinogenesis

KW - Evolution

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Multistage carcinogenesis in Barrett's esophagus

Abstract

Keywords

ASJC Scopus subject areas

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