Multiscale analytic continuation approach to nanosystem simulation: Applications to virus electrostatics

Abhishek Singharoy, Anastasia M. Yesnik, Peter Ortoleva

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Electrostatic effects in nanosystems are understood via a physical picture built on their multiscale character and the distinct behavior of mobile ions versus charge groups fixed to the nanostructure. The Poisson-Boltzmann equation is nondimensionalized to introduce a factor λ that measures the density of mobile ion charge versus that due to fixed charges; the diffusive smearing and volume exclusion effects of the former tend to diminish its value relative to that from the fixed charges. We introduce the ratio σ of the average nearest-neighbor atom distance to the characteristic size of the features of the nanostructure of interest (e.g., a viral capsomer). We show that a unified treatment (i.e., λσ) and a perturbation expansion around σ=0 yields, through analytic continuation, an approximation to the electrostatic potential of high accuracy and computational efficiency. The approach was analyzed via Pad́ approximants and demonstrated on viral system electrostatics; it can be generalized to accommodate extended Poisson-Boltzmann models, and has wider applicability to nonequilibrium electrodiffusion and many-particle quantum systems.

Original languageEnglish (US)
Article number174112
JournalJournal of Chemical Physics
Volume132
Issue number17
DOIs
StatePublished - May 7 2010

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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