Multiple origins of prokaryotic and eukaryotic single-stranded DNA viruses from bacterial and archaeal plasmids

Darius Kazlauskas, Arvind Varsani, Eugene V. Koonin, Mart Krupovic

Research output: Contribution to journalArticle

Abstract

Single-stranded (ss) DNA viruses are a major component of the earth virome. In particular, the circular, Rep-encoding ssDNA (CRESS-DNA) viruses show high diversity and abundance in various habitats. By combining sequence similarity network and phylogenetic analyses of the replication proteins (Rep) belonging to the HUH endonuclease superfamily, we show that the replication machinery of the CRESS-DNA viruses evolved, on three independent occasions, from the Reps of bacterial rolling circle-replicating plasmids. The CRESS-DNA viruses emerged via recombination between such plasmids and cDNA copies of capsid genes of eukaryotic positive-sense RNA viruses. Similarly, the rep genes of prokaryotic DNA viruses appear to have evolved from HUH endonuclease genes of various bacterial and archaeal plasmids. Our findings also suggest that eukaryotic polyomaviruses and papillomaviruses with dsDNA genomes have evolved via parvoviruses from CRESS-DNA viruses. Collectively, our results shed light on the complex evolutionary history of a major class of viruses revealing its polyphyletic origins.

Original languageEnglish (US)
Number of pages1
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Jul 31 2019

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plasmids
DNA Viruses
Single-Stranded DNA
viruses
Viruses
Plasmids
deoxyribonucleic acid
Endonucleases
coding
Genes
genes
Archaeal Genes
Bacterial Genes
Polyomavirus
Parvovirus
Capsid
RNA Viruses
Genetic Recombination
Ecosystem
proteins

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Multiple origins of prokaryotic and eukaryotic single-stranded DNA viruses from bacterial and archaeal plasmids. / Kazlauskas, Darius; Varsani, Arvind; Koonin, Eugene V.; Krupovic, Mart.

In: Nature communications, Vol. 10, No. 1, 31.07.2019.

Research output: Contribution to journalArticle

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