Multi-site incorporation of bioactive matrices into MEMS-based neural probes

Justin C. Williams, Matthew M. Holecko, Stephen Massia, Patrick Rousche, Daryl R. Kipke

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Methods are presented to incorporate polymer-based bioactive matrices into micro-fabricated implantable microelectrode arrays. Using simple techniques, hydrogels infused with bioactive molecules are deposited within wells in the substrate of the device. This method allows local drug delivery without increasing the footprint of the device. In addition, each well can be loaded individually, allowing spatial and temporal control over diffusion gradients in the microenvironment of the implanted neural interface probe. In vivo testing verified the following: diffusion of the bioactive molecules, integration of the bioactive molecules with the intended neural target and concurrent extracellular recording using nearby electrodes. These results support the feasibility of using polymer gels to deliver bioactive molecules to the region close to microelectrode shanks. This technique for microdrug delivery may serve as a means to intervene with the initial phases of the neuroinflammatory tissue response to permanently implanted microelectrode arrays.

Original languageEnglish (US)
JournalJournal of Neural Engineering
Volume2
Issue number4
DOIs
StatePublished - Dec 2005

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Micro-Electrical-Mechanical Systems
Microelectrodes
MEMS
Molecules
Polymers
Equipment and Supplies
Hydrogels
Electrodes
Gels
Drug delivery
Tissue
Pharmaceutical Preparations
Testing
Substrates

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Neuroscience (miscellaneous)

Cite this

Multi-site incorporation of bioactive matrices into MEMS-based neural probes. / Williams, Justin C.; Holecko, Matthew M.; Massia, Stephen; Rousche, Patrick; Kipke, Daryl R.

In: Journal of Neural Engineering, Vol. 2, No. 4, 12.2005.

Research output: Contribution to journalArticle

Williams, Justin C. ; Holecko, Matthew M. ; Massia, Stephen ; Rousche, Patrick ; Kipke, Daryl R. / Multi-site incorporation of bioactive matrices into MEMS-based neural probes. In: Journal of Neural Engineering. 2005 ; Vol. 2, No. 4.
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