MRI assessment of changes in tumor oxygenation post hypoxia-targeted therapy

Shubhangi Agarwal, Rohini Vidya Shankar, Landon J. Inge, Vikram Kodibagkar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In the tumor microenvironment, the combination of compromised oxygen supply and high demand results in formation of regions of acute and chronic hypoxia, which promotes metastasis, proliferation, resistance to chemo and radiotherapy and poor prognosis. Targeted, non-invasive in vivo imaging of hypoxia has the potential to determine regions with poor oxygenation in the target and differentiate between normoxic vs hypoxic tissues. MRI provides a powerful platform for generating quantitative maps of hypoxia with the use of a novel pO2 measuring technique PISTOL (Proton imaging of siloxanes to map tissue oxygenation levels) which could impact the therapeutic choices. In the present study, PISTOL was used to determine the changes in oxygenation of tumor in pre-clinical models of NSCLC (H1975) and epidermoid carcinoma (A431) in response to tirapzamine (TPZ), a hypoxia activated chemotherapeutic. The tumor volume measurements indicate that tirapazamine was more effective in slowing the tumor growth in H1975 as compared to A431 tumors, even though lower baseline pO2was observed in A431 as compared to H1975 tumors. These results indicate that other factors such as tumor perfusion (essential for delivering TPZ) and relative expression of nitroreductases (essential for activating TPZ) may play an important role in conjunction with pO2.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9417
ISBN (Print)9781628415070
DOIs
StatePublished - 2015
EventMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States
Duration: Feb 24 2015Feb 26 2015

Other

OtherMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityOrlando
Period2/24/152/26/15

Fingerprint

Oxygenation
oxygenation
hypoxia
Magnetic resonance imaging
Tumors
therapy
tumors
Siloxanes
tirapazamine
Neoplasms
Protons
siloxanes
Tissue
Nitroreductases
Imaging techniques
Therapeutics
Tumor Microenvironment
Tumor Burden
Oxygen supply
Volume measurement

Keywords

  • Epidermoid carcinoma
  • Hypoxia
  • MRI
  • NSCLC
  • PISTOL

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Agarwal, S., Shankar, R. V., Inge, L. J., & Kodibagkar, V. (2015). MRI assessment of changes in tumor oxygenation post hypoxia-targeted therapy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9417). [941714] SPIE. https://doi.org/10.1117/12.2083926

MRI assessment of changes in tumor oxygenation post hypoxia-targeted therapy. / Agarwal, Shubhangi; Shankar, Rohini Vidya; Inge, Landon J.; Kodibagkar, Vikram.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9417 SPIE, 2015. 941714.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Agarwal, S, Shankar, RV, Inge, LJ & Kodibagkar, V 2015, MRI assessment of changes in tumor oxygenation post hypoxia-targeted therapy. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9417, 941714, SPIE, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, Orlando, United States, 2/24/15. https://doi.org/10.1117/12.2083926
Agarwal S, Shankar RV, Inge LJ, Kodibagkar V. MRI assessment of changes in tumor oxygenation post hypoxia-targeted therapy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9417. SPIE. 2015. 941714 https://doi.org/10.1117/12.2083926
Agarwal, Shubhangi ; Shankar, Rohini Vidya ; Inge, Landon J. ; Kodibagkar, Vikram. / MRI assessment of changes in tumor oxygenation post hypoxia-targeted therapy. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9417 SPIE, 2015.
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