MR imaging of diffusion of 3He gas in healthy and diseased lungs

Brian T. Saam, Dmitriy A. Yablonskiy, Vikram D. Kodibagkar, Jason C. Leawoods, David S. Gierada, Joel D. Cooper, Stephen S. Lefrak, Mark S. Conradi

Research output: Contribution to journalArticle

262 Scopus citations

Abstract

Hyperpolarized He gas MRI was used to form maps of the effective diffusivity of gas in human lungs, images of diffusion as well as spin density are presented from a study of 11 healthy volunteers and 5 patients with severe emphysema. The effective rate of diffusion, D(e), of the gas is reduced by the alveolar walls; tissue destruction in emphysema is hypothesized to result in larger D(e). Indeed, the mean value of Do in the emphysematous lungs is found here to be about 2.5 times that of healthy lungs, although still smaller than the unrestricted diffusivity of He in free air. Histograms of D(e) values across coronal slices are presented. The results are discussed in terms of spatial variations, variations among individuals, healthy and diseased, and variations due to changes in lung volume. 174-179 (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)174-179
Number of pages6
JournalMagnetic Resonance in Medicine
Volume44
Issue number2
DOIs
StatePublished - Aug 23 2000
Externally publishedYes

Keywords

  • Diffusion
  • Gas
  • He
  • Hyperpolarized gas
  • Lungs

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'MR imaging of diffusion of <sup>3</sup>He gas in healthy and diseased lungs'. Together they form a unique fingerprint.

  • Cite this

    Saam, B. T., Yablonskiy, D. A., Kodibagkar, V. D., Leawoods, J. C., Gierada, D. S., Cooper, J. D., Lefrak, S. S., & Conradi, M. S. (2000). MR imaging of diffusion of 3He gas in healthy and diseased lungs. Magnetic Resonance in Medicine, 44(2), 174-179. https://doi.org/10.1002/1522-2594(200008)44:2<174::AID-MRM2>3.0.CO;2-4