Movable microprobes for the brain

Jitendran Muthuswamy, M. Okandan, A. Gilletti, M. Baker, T. Jain, N. Jackson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Neuroscientists have long recognized the significance of using microelectrode arrays for recording extracellular potentials from populations of neurons, and a number of such devices have been developed so far. However, current implantable microelectrode technologies to monitor single neuronal function in-vivo often fail in chronic situations primarily due to mechanical drift in positioning mechanisms, micromotion of brain tissue and gliosis around the implant site. We report here two novel microactuator (electrostatic and electrothermal) and associated microelectrode technologies that enable precise repositioning of microelectrodes after implantation in the event of failure or otherwise. Both microactuator technologies are capable of bi-directional motion of the microelectrodes. The movement resolution of electrostatic microactuators is in the order of 1 μm and that of the thermal microactuators in the order of 9 μm. However, the thermal microactuators are mechanically more robust. Multi-unit data obtained from in vivo animal models using both technologies are reported. This is first successful demonstration of a micromachining approach to the fabrication of movable microprobes. These movable microprobes will potentially lead to better long-term interfaces with single neurons in vivo.

Original languageEnglish (US)
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages86-87
Number of pages2
DOIs
StatePublished - Dec 1 2005
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: May 12 2005May 15 2005

Publication series

Name2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume2005

Other

Other2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
CountryUnited States
CityOahu, HI
Period5/12/055/15/05

ASJC Scopus subject areas

  • Engineering(all)

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    Muthuswamy, J., Okandan, M., Gilletti, A., Baker, M., Jain, T., & Jackson, N. (2005). Movable microprobes for the brain. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (pp. 86-87). [1548390] (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology; Vol. 2005). https://doi.org/10.1109/MMB.2005.1548390