Motor subtypes of Parkinson’s disease can be identified by frequency component of postural stability

Saba Rezvanian, Thurmon Lockhart, Christopher Frames, Rahul Soangra, Abraham Lieberman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Parkinson’s disease (PD) can be divided into two subtypes based on clinical features—namely tremor dominant (TD) and postural instability and gait difficulty (PIGD). This categorization is important at the early stage of PD, since identifying the subtypes can help to predict the clinical progression of the disease. Accordingly, correctly diagnosing subtypes is critical in initiating appropriate early interventions and tracking the progression of the disease. However, as the disease progresses, it becomes increasingly difficult to further distinguish those attributes that are relevant to the subtypes. In this study, we investigated whether a method using the standing center of pressure (COP) time series data can separate two subtypes of PD by looking at the frequency component of COP (i.e., COP position and speed). Thirty-six participants diagnosed with PD were evaluated, with their bare feet on the force platform, and were instructed to stand upright with their arms by their sides for 20 s (with their eyes open and closed), which is consistent with the traditional COP measures. Fast Fourier transform (FFT) and wavelet transform (WT) were performed to distinguish between the motor subtypes using the COP measures. The TD group exhibited larger amplitudes at the frequency range of 3-7 Hz when compared to the PIGD group. Both the FFT and WT methods were able to differentiate the subtypes. COP time series information can be used to differentiate between the two motor subtypes of PD, using the frequency component of postural stability.

Original languageEnglish (US)
Article number1102
JournalSensors (Switzerland)
Volume18
Issue number4
DOIs
StatePublished - Apr 5 2018

Fingerprint

center of pressure
Parkinson disease
Parkinson Disease
Pressure
gait
tremors
Wavelet Analysis
Tremor
Fourier Analysis
Gait
progressions
wavelet analysis
Disease Progression
Fast Fourier transforms
Wavelet transforms
Time series
Foot
Arm
platforms
frequency ranges

Keywords

  • Center of pressure (COP)
  • Fast Fourier transform (FFT)
  • Parkinson’s disease (PD)
  • Postural instability and gait difficulty (PIGD)
  • Tremor dominant (TD)
  • Wavelet transform (WT)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Biochemistry
  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Motor subtypes of Parkinson’s disease can be identified by frequency component of postural stability. / Rezvanian, Saba; Lockhart, Thurmon; Frames, Christopher; Soangra, Rahul; Lieberman, Abraham.

In: Sensors (Switzerland), Vol. 18, No. 4, 1102, 05.04.2018.

Research output: Contribution to journalArticle

Rezvanian, Saba ; Lockhart, Thurmon ; Frames, Christopher ; Soangra, Rahul ; Lieberman, Abraham. / Motor subtypes of Parkinson’s disease can be identified by frequency component of postural stability. In: Sensors (Switzerland). 2018 ; Vol. 18, No. 4.
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