Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex

Jeffrey Kleim, Scott Barbay, Natalie R. Cooper, Theresa M. Hogg, Chelsea N. Reidel, Michael S. Remple, Randolph J. Nudo

Research output: Contribution to journalArticle

349 Citations (Scopus)

Abstract

The regional specificity and functional significance of learning-dependent synaptogenesis within physiologically defined regions of the adult motor cortex are described. In comparison to rats in a motor activity control group, rats trained on a skilled reaching task exhibited an areal expansion of wrist and digit movement representations within the motor cortex. No expansion of hindlimb representations was seen. This functional reorganization was restricted to the caudal forelimb area, as no differences in the topography of movement representations were observed within the rostral forelimb area. Paralleling the physiological changes, trained animals also had significantly more synapses per neuron than controls within layer V of the caudal forelimb area. No differences in the number of synapses per neuron were found in either the rostral forelimb or hindlimb areas. This is the first demonstration of the co-occurrence of functional and structural plasticity within the same cortical regions and provides strong evidence that synapse formation may play a role in supporting learning-dependent changes in cortical function.

Original languageEnglish (US)
Pages (from-to)63-77
Number of pages15
JournalNeurobiology of Learning and Memory
Volume77
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Forelimb
Motor Cortex
Learning
Synapses
Hindlimb
Neurons
Wrist
Motor Activity
Control Groups

Keywords

  • Intracortical microstimulation
  • Motor cortex
  • Motor learning
  • Plasticity
  • Rat
  • Synaptogenesis

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. / Kleim, Jeffrey; Barbay, Scott; Cooper, Natalie R.; Hogg, Theresa M.; Reidel, Chelsea N.; Remple, Michael S.; Nudo, Randolph J.

In: Neurobiology of Learning and Memory, Vol. 77, No. 1, 2002, p. 63-77.

Research output: Contribution to journalArticle

Kleim, Jeffrey ; Barbay, Scott ; Cooper, Natalie R. ; Hogg, Theresa M. ; Reidel, Chelsea N. ; Remple, Michael S. ; Nudo, Randolph J. / Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. In: Neurobiology of Learning and Memory. 2002 ; Vol. 77, No. 1. pp. 63-77.
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