Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult

Jeffrey Kleim, Rochelle Bruneau, Penny VandenBerg, Erin MacDonald, Renee Mulrooney, David Pocock

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimulation in combination with motor rehabilitation. Adult rats were trained to criterion on a single pellet reaching task before ICMS was used to derive maps of movement representations within forelimb motor cortex contralateral to the trained paw. All animals then received a focal ischemic infarct within the motor map. A cortical surface electrode was implanted over the motor cortex. Low levels of electrical stimulation were applied during rehabilitative training on the same reaching task for 10 days and ICMS used to derive a second motor map. Results showed that both monopolar and bipolar cortical stimulation significantly enhanced motor recovery and increased the area of cortex from which microstimulation movements could be evoked. The results demonstrate the behavioral and neurophysiological benefits of cortical stimulation in combination with rehabilitation for recovery from stroke.

Original languageEnglish (US)
Pages (from-to)789-793
Number of pages5
JournalNeurological Research
Volume25
Issue number8
DOIs
StatePublished - Dec 2003
Externally publishedYes

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Motor Cortex
Implanted Electrodes
Forelimb
Recovery of Function
Electric Stimulation
Rodentia
Rehabilitation
Ischemia
Stroke
Stroke Rehabilitation

Keywords

  • Cortical stimulation
  • Intracortical microstimulation
  • Ischemia
  • Motor cortex
  • Rehabilitation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult. / Kleim, Jeffrey; Bruneau, Rochelle; VandenBerg, Penny; MacDonald, Erin; Mulrooney, Renee; Pocock, David.

In: Neurological Research, Vol. 25, No. 8, 12.2003, p. 789-793.

Research output: Contribution to journalArticle

Kleim, Jeffrey ; Bruneau, Rochelle ; VandenBerg, Penny ; MacDonald, Erin ; Mulrooney, Renee ; Pocock, David. / Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult. In: Neurological Research. 2003 ; Vol. 25, No. 8. pp. 789-793.
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