Morphological changes in the hippocampal CA3 region induced by non- invasive glucocorticoid administration: A paradox

Ana María Magariños, Miles Orchinik, Bruce S. McEwen

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

Repeated stress induces atrophy, or remodeling, of apical dendrites in hippocampal CA3 pyramidal neurons. In rats, the stress effect is blocked by adrenal steroid synthesis inhibitors, and mimicked by daily injection of corticosterone. We report that non-invasive administration of corticosterone in the drinking water (400 μg/ml) also produced atrophy of apical dendrites in CA3. Unexpectedly, the combination of daily stress and oral corticosterone negated the effects of either treatment alone, and no changes in the apical dendritic length or branching pattern of CA3 pyramidal neurons were observed compared to control unstressed rats.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalBrain Research
Volume809
Issue number2
DOIs
StatePublished - Nov 2 1998

Keywords

  • Corticosterone
  • Dendritic atrophy
  • Golgi impregnation
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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