Abstract
Repeated stress induces atrophy, or remodeling, of apical dendrites in hippocampal CA3 pyramidal neurons. In rats, the stress effect is blocked by adrenal steroid synthesis inhibitors, and mimicked by daily injection of corticosterone. We report that non-invasive administration of corticosterone in the drinking water (400 μg/ml) also produced atrophy of apical dendrites in CA3. Unexpectedly, the combination of daily stress and oral corticosterone negated the effects of either treatment alone, and no changes in the apical dendritic length or branching pattern of CA3 pyramidal neurons were observed compared to control unstressed rats.
Original language | English (US) |
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Pages (from-to) | 314-318 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 809 |
Issue number | 2 |
DOIs | |
State | Published - Nov 2 1998 |
Keywords
- Corticosterone
- Dendritic atrophy
- Golgi impregnation
- Stress
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology