Monolithic quartz platform for cellular contact guidance

Michael C. Robitaille, Joseph A. Christodoulides, Jinny L. Liu, Wonmo Kang, Jeff M. Byers, Katarina Doctor, Dmitry Kozak, Marc P. Raphael

Research output: Contribution to journalArticlepeer-review

Abstract

Contact guidance is vital to many physiological processes, yet is still poorly understood. This is partly due to the variability of experimental platforms, making comparisons difficult. To combat this, a multiplexed approach was used to fabricate topographical cues on single quartz coverslips for high-throughput screening. Furthermore, this method offers control of surface roughness and protein adsorption characterization, two critical aspects to the in vitro environment often overlooked in contact guidance platforms. The quartz surface can be regenerated, is compatible with versatile microscopy modes, and can scale up for manufacturing offering a novel platform that could serve as a potential standard assay.

Original languageEnglish (US)
Pages (from-to)242-251
Number of pages10
JournalMRS Communications
Volume10
Issue number2
DOIs
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Materials Science(all)

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