Monolithic quartz platform for cellular contact guidance

Michael C. Robitaille; Joseph A. Christodoulides; Jinny L. Liu; Wonmo Kang; Jeff M. Byers; Katarina Doctor; Dmitry Kozak; Marc P. Raphael

doi:10.1557/mrc.2020.15

Monolithic quartz platform for cellular contact guidance

Michael C. Robitaille, Joseph A. Christodoulides, Jinny L. Liu, Wonmo Kang, Jeff M. Byers, Katarina Doctor, Dmitry Kozak, Marc P. Raphael

Mechanical and Aerospace Engineering

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Contact guidance is vital to many physiological processes, yet is still poorly understood. This is partly due to the variability of experimental platforms, making comparisons difficult. To combat this, a multiplexed approach was used to fabricate topographical cues on single quartz coverslips for high-throughput screening. Furthermore, this method offers control of surface roughness and protein adsorption characterization, two critical aspects to the in vitro environment often overlooked in contact guidance platforms. The quartz surface can be regenerated, is compatible with versatile microscopy modes, and can scale up for manufacturing offering a novel platform that could serve as a potential standard assay.

Original language	English (US)
Pages (from-to)	242-251
Number of pages	10
Journal	MRS Communications
Volume	10
Issue number	2
DOIs	https://doi.org/10.1557/mrc.2020.15
State	Published - Jun 1 2020

ASJC Scopus subject areas

General Materials Science

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abstract = "Contact guidance is vital to many physiological processes, yet is still poorly understood. This is partly due to the variability of experimental platforms, making comparisons difficult. To combat this, a multiplexed approach was used to fabricate topographical cues on single quartz coverslips for high-throughput screening. Furthermore, this method offers control of surface roughness and protein adsorption characterization, two critical aspects to the in vitro environment often overlooked in contact guidance platforms. The quartz surface can be regenerated, is compatible with versatile microscopy modes, and can scale up for manufacturing offering a novel platform that could serve as a potential standard assay.",

author = "Robitaille, {Michael C.} and Christodoulides, {Joseph A.} and Liu, {Jinny L.} and Wonmo Kang and Byers, {Jeff M.} and Katarina Doctor and Dmitry Kozak and Raphael, {Marc P.}",

note = "Funding Information: M.C.R. gratefully acknowledges support from the National Research Council Research Associateship Program and the Jerome and Isabella Karle Distinguished Scholar Fellowship Program. Funding for this project was provided by the Office of Naval Research through the Naval Research Laboratory's Basic Research Program. Publisher Copyright: Copyright {\textcopyright} Materials Research Society 2020.",

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doi = "10.1557/mrc.2020.15",

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AU - Robitaille, Michael C.

AU - Christodoulides, Joseph A.

AU - Liu, Jinny L.

AU - Kang, Wonmo

AU - Byers, Jeff M.

AU - Doctor, Katarina

AU - Kozak, Dmitry

AU - Raphael, Marc P.

N1 - Funding Information: M.C.R. gratefully acknowledges support from the National Research Council Research Associateship Program and the Jerome and Isabella Karle Distinguished Scholar Fellowship Program. Funding for this project was provided by the Office of Naval Research through the Naval Research Laboratory's Basic Research Program. Publisher Copyright: Copyright © Materials Research Society 2020.

PY - 2020/6/1

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N2 - Contact guidance is vital to many physiological processes, yet is still poorly understood. This is partly due to the variability of experimental platforms, making comparisons difficult. To combat this, a multiplexed approach was used to fabricate topographical cues on single quartz coverslips for high-throughput screening. Furthermore, this method offers control of surface roughness and protein adsorption characterization, two critical aspects to the in vitro environment often overlooked in contact guidance platforms. The quartz surface can be regenerated, is compatible with versatile microscopy modes, and can scale up for manufacturing offering a novel platform that could serve as a potential standard assay.

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Monolithic quartz platform for cellular contact guidance

Abstract

ASJC Scopus subject areas

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