Monocyte Immune Cell Response and Copper Status in Beef Steers That Grazed Endophyte-Infected Tall Fescue 1

K. E. Saker, V. G. Allen, J. Kalnitsky, Craig Thatcher, W. S. Swecker, J. P. Fontenot

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A 3-yr study was conducted to evaluate immune response and Cu status of yearling beef steers as a consequence of grazing tall fescue (Festuca arundinacea Schreb.) infected (E+) with the endophyte fungus Neotyphodium coenophialum ([Morgan-Jones and Gams] Glenn, Bacon, and Hanlin). During a preliminary study in 1994, 24 weanling Angus and Angus x Hereford steers were blocked by breed and weight (initial BW 271 kg; SD 25) and were randomized to E+ and low endophyte (E-) fescue in pastures at Glade Spring, VA. Grazing began in April and was discontinued in July. In 1995 and 1996, 24 weanling Angus and Angus x Hereford steers (initial BW 249 kg, SD 20 and 240 kg, SD 15, respectively) were randomized to the E+ and E- pastures at Glade Spring during each year. Grazing began in April and continued until September in 1995 and October in 1996. In 1994, steers that grazed E+ fescue exhibited lower (P < .05) phagocytic activity, major histocompatibility complex (MHC) class II expression, ceruloplasmin, and serum Cu than steers that grazed E- tall fescue. During 1995, steers grazing E+ fescue had lower (P < .05) phagocytic activity and MHC class II expression than steers that grazed E- fescue. In 1996, one-half of the steers within each paddock received a Cu oxide bolus at the beginning of the grazing season. During 1996, phagocytic activity was lower (P < .01) and MHC class II expression tended (P < .07) to be lower in steers that grazed E+ tall fescue than in steers that grazed E- tall fescue. Copper supplementation increased (P < .05) MHC class II expression in July regardless of endophyte status over nonsupplemented steers. Steers that grazed E- tall fescue had higher (P < .05) plasma or serum Cu concentrations than steers that grazed E+ tall fescue in each year of the study. These data indicate that the endophyte compromised the immune function of grazing steers, and the data suggest a relationship with depressed Cu status.

Original languageEnglish (US)
Pages (from-to)2694-2700
Number of pages7
JournalJournal of Animal Science
Volume76
Issue number10
StatePublished - Oct 1998
Externally publishedYes

Fingerprint

Endophytes
Festuca arundinacea
endophytes
Major Histocompatibility Complex
beef cattle
monocytes
Copper
Monocytes
copper
Neotyphodium
Festuca
cells
major histocompatibility complex
grazing
Angus
Ceruloplasmin
Serum
Oxides
phagocytosis
Fungi

Keywords

  • Copper
  • Endophytes
  • Forage
  • Immune Response
  • Minerals
  • Steers

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Saker, K. E., Allen, V. G., Kalnitsky, J., Thatcher, C., Swecker, W. S., & Fontenot, J. P. (1998). Monocyte Immune Cell Response and Copper Status in Beef Steers That Grazed Endophyte-Infected Tall Fescue 1. Journal of Animal Science, 76(10), 2694-2700.

Monocyte Immune Cell Response and Copper Status in Beef Steers That Grazed Endophyte-Infected Tall Fescue 1. / Saker, K. E.; Allen, V. G.; Kalnitsky, J.; Thatcher, Craig; Swecker, W. S.; Fontenot, J. P.

In: Journal of Animal Science, Vol. 76, No. 10, 10.1998, p. 2694-2700.

Research output: Contribution to journalArticle

Saker, KE, Allen, VG, Kalnitsky, J, Thatcher, C, Swecker, WS & Fontenot, JP 1998, 'Monocyte Immune Cell Response and Copper Status in Beef Steers That Grazed Endophyte-Infected Tall Fescue 1', Journal of Animal Science, vol. 76, no. 10, pp. 2694-2700.
Saker, K. E. ; Allen, V. G. ; Kalnitsky, J. ; Thatcher, Craig ; Swecker, W. S. ; Fontenot, J. P. / Monocyte Immune Cell Response and Copper Status in Beef Steers That Grazed Endophyte-Infected Tall Fescue 1. In: Journal of Animal Science. 1998 ; Vol. 76, No. 10. pp. 2694-2700.
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