TY - JOUR
T1 - Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes
AU - Zhang, Jingqing
AU - Landry, Markita P.
AU - Barone, Paul W.
AU - Kim, Jong Ho
AU - Lin, Shangchao
AU - Ulissi, Zachary W.
AU - Lin, Dahua
AU - Mu, Bin
AU - Boghossian, Ardemis A.
AU - Hilmer, Andrew J.
AU - Rwei, Alina
AU - Hinckley, Allison C.
AU - Kruss, Sebastian
AU - Shandell, Mia A.
AU - Nair, Nitish
AU - Blake, Steven
AU - Şen, Fatih
AU - Şen, Selda
AU - Croy, Robert G.
AU - Li, Deyu
AU - Yum, Kyungsuk
AU - Ahn, Jin Ho
AU - Jin, Hong
AU - Heller, Daniel A.
AU - Essigmann, John M.
AU - Blankschtein, Daniel
AU - Strano, Michael S.
N1 - Funding Information:
The authors thank L. Trudel for her assistance with cell culture. The authors thank D. Wittrup, C. Love and V. Sresht for discussions. This work made use of the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation (grant no. OCI-1053575). M.S.S. acknowledges a grant from the Army Research Office and support via award no. 64655-CH-ISN to the Institute for Solider Nanotechnologies. D.A.H. acknowledges the Damon Runyon Cancer Research Foundation. A.A.B. is funded by the National Defense Science & Engineering Graduate Fellowship. A.J.H. acknowledges funding from the Department of Energy SCGF programme (contract no. DE-AC05-06OR23100). Z.W.U. acknowledges support from the Department of Energy CSGF (DOE grant DE-FG02-97ER25308). M.P.L. acknowledges an NSF postdoctoral research fellowship (award no. DBI-1306229). S.K. was supported by a fellowship from the Deutsche Forschungsmeinschaft (DFG).
PY - 2013/12
Y1 - 2013/12
N2 - Understanding molecular recognition is of fundamental importance in applications such as therapeutics, chemical catalysis and sensor design. The most common recognition motifs involve biological macromolecules such as antibodies and aptamers. The key to biorecognition consists of a unique three-dimensional structure formed by a folded and constrained bioheteropolymer that creates a binding pocket, or an interface, able to recognize a specific molecule. Here, we show that synthetic heteropolymers, once constrained onto a single-walled carbon nanotube by chemical adsorption, also form a new corona phase that exhibits highly selective recognition for specific molecules. To prove the generality of this phenomenon, we report three examples of heteropolymer-nanotube recognition complexes for riboflavin, L-thyroxine and oestradiol. In each case, the recognition was predicted using a two-dimensional thermodynamic model of surface interactions in which the dissociation constants can be tuned by perturbing the chemical structure of the heteropolymer. Moreover, these complexes can be used as new types of spatiotemporal sensors based on modulation of the carbon nanotube photoemission in the near-infrared, as we show by tracking riboflavin diffusion in murine macrophages.
AB - Understanding molecular recognition is of fundamental importance in applications such as therapeutics, chemical catalysis and sensor design. The most common recognition motifs involve biological macromolecules such as antibodies and aptamers. The key to biorecognition consists of a unique three-dimensional structure formed by a folded and constrained bioheteropolymer that creates a binding pocket, or an interface, able to recognize a specific molecule. Here, we show that synthetic heteropolymers, once constrained onto a single-walled carbon nanotube by chemical adsorption, also form a new corona phase that exhibits highly selective recognition for specific molecules. To prove the generality of this phenomenon, we report three examples of heteropolymer-nanotube recognition complexes for riboflavin, L-thyroxine and oestradiol. In each case, the recognition was predicted using a two-dimensional thermodynamic model of surface interactions in which the dissociation constants can be tuned by perturbing the chemical structure of the heteropolymer. Moreover, these complexes can be used as new types of spatiotemporal sensors based on modulation of the carbon nanotube photoemission in the near-infrared, as we show by tracking riboflavin diffusion in murine macrophages.
UR - http://www.scopus.com/inward/record.url?scp=84890446448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890446448&partnerID=8YFLogxK
U2 - 10.1038/nnano.2013.236
DO - 10.1038/nnano.2013.236
M3 - Article
C2 - 24270641
AN - SCOPUS:84890446448
SN - 1748-3387
VL - 8
SP - 959
EP - 968
JO - Nature nanotechnology
JF - Nature nanotechnology
IS - 12
ER -