Molecular fMRI

Benjamin B. Bartelle, Ali Barandov, Alan Jasanoff

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Comprehensive analysis of brain function depends on understanding the dynamics of diverse neural signaling processes over large tissue volumes in intact animals and humans. Most existing approaches to measuring brain signaling suffer from limited tissue penetration, poor resolution, or lack of specificity for well-defined neural events. Herewediscuss a new brain activity mapping method that overcomes some of these problems by combining MRI with contrast agents sensitive to neural signaling. The goal of this “molecular fMRI” approach is to permit noninvasive whole-brain neuroimaging with specificity and resolution approaching current optical neuroimaging methods. In this article, we describe the context and need for molecular fMRI as well as the state of the technology today. We explain how major types of MRI probes work and how they can be sensitized to neurobiological processes, such as neurotransmitter release, calcium signaling, and gene expression changes. We comment both on past work in the field and on challenges and promising avenues for future development.

Original languageEnglish (US)
Pages (from-to)4139-4148
Number of pages10
JournalJournal of Neuroscience
Volume36
Issue number15
DOIs
StatePublished - Apr 13 2016
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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