Abstract
The sequences of surface adsorption of fibrinogen (Fgn) responsible for phagocyte attraction and adhesion were examined using plasmin-generated Fgn fragments. Polyethylene terephthalate (PET) disks were cut and sterilized in ethanol. Protein coating was achieved by incubating hydrated PET disks with solutions of albumin, Fgn, Fgn fragments, peptide-linked albumin or saline at room temperature for 16 hours under sterile conditions. Samples of PET were implanted in Swiss Webster mice to serve as an in vivo model for assessing inflammatory cell responses to biomaterials. Experimental results suggest that the interactions between the Fgn and macrophage are important in the accumulation of phagocytes on implant surfaces and early inflammatory responses.
| Original language | English (US) |
|---|---|
| Title of host publication | Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium |
| Editors | Anon |
| Place of Publication | St. Louis Park, MN, United States |
| Publisher | Soc for Biomaterials |
| Pages | 9 |
| Number of pages | 1 |
| Volume | 1 |
| State | Published - 1996 |
| Externally published | Yes |
| Event | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996 |
Other
| Other | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) |
|---|---|
| City | Toronto, Can |
| Period | 5/29/96 → 6/2/96 |
ASJC Scopus subject areas
- General Materials Science