Molecular determinants of acute inflammatory responses to biomaterials

L. Tang, Tatiana Ugarova, E. F. Plow, J. W. Eaten

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The sequences of surface adsorption of fibrinogen (Fgn) responsible for phagocyte attraction and adhesion were examined using plasmin-generated Fgn fragments. Polyethylene terephthalate (PET) disks were cut and sterilized in ethanol. Protein coating was achieved by incubating hydrated PET disks with solutions of albumin, Fgn, Fgn fragments, peptide-linked albumin or saline at room temperature for 16 hours under sterile conditions. Samples of PET were implanted in Swiss Webster mice to serve as an in vivo model for assessing inflammatory cell responses to biomaterials. Experimental results suggest that the interactions between the Fgn and macrophage are important in the accumulation of phagocytes on implant surfaces and early inflammatory responses.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
Place of PublicationSt. Louis Park, MN, United States
PublisherSoc for Biomaterials
Number of pages1
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996


OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can

ASJC Scopus subject areas

  • Materials Science(all)


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