Molecular clocks: Four decades of evolution

Sudhir Kumar

Research output: Contribution to journalReview article

205 Scopus citations


During the past four decades, the molecular-clock hypothesis has provided an invaluable tool for building evolutionary timescales, and has served as a null model for testing evolutionary and mutation rates in different species. Molecular clocks have also influenced the development of theories of molecular evolution. As DNA-sequencing technologies have progressed, the use of molecular clocks has increased, with a profound effect on our understanding of the temporal diversification of species and genomes.

Original languageEnglish (US)
Pages (from-to)654-662
Number of pages9
JournalNature Reviews Genetics
Issue number8
StatePublished - Aug 1 2005


ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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