TY - JOUR
T1 - Molecular clocks
T2 - Four decades of evolution
AU - Kumar, Sudhir
N1 - Funding Information:
We would like to acknowledge the support of the US National Institutes of Health, the Israel Science Foundation, the Israel Cancer Research Fund, the Belfer Foundation and the Rosetrees Trust.
Funding Information:
I thank A. Filipski and S.B. Hedges for their insights and for a critical review of different versions of this manuscript. G. Valente and V. Swarna helped in locating references and compiling data; D. Desonie provided editorial support; and S. Subramanian, C. Kuslich, J.E. Blair and A. Briscoe provided scientific feedback on an earlier draft. This work was supported by a research grant from the US National Institutes of Health.
PY - 2005/8
Y1 - 2005/8
N2 - During the past four decades, the molecular-clock hypothesis has provided an invaluable tool for building evolutionary timescales, and has served as a null model for testing evolutionary and mutation rates in different species. Molecular clocks have also influenced the development of theories of molecular evolution. As DNA-sequencing technologies have progressed, the use of molecular clocks has increased, with a profound effect on our understanding of the temporal diversification of species and genomes.
AB - During the past four decades, the molecular-clock hypothesis has provided an invaluable tool for building evolutionary timescales, and has served as a null model for testing evolutionary and mutation rates in different species. Molecular clocks have also influenced the development of theories of molecular evolution. As DNA-sequencing technologies have progressed, the use of molecular clocks has increased, with a profound effect on our understanding of the temporal diversification of species and genomes.
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U2 - 10.1038/nrg1659
DO - 10.1038/nrg1659
M3 - Review article
C2 - 16136655
AN - SCOPUS:22944437097
SN - 1471-0056
VL - 6
SP - 654
EP - 662
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 8
ER -