Modulation of NF-κB signalling by microbial pathogens

Research output: Contribution to journalReview article

147 Citations (Scopus)

Abstract

The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host response to infection by microbial pathogens, by orchestrating the innate and acquired host immune responses. The NF-κB proteins are activated by diverse signalling pathways that originate from many different cellular receptors and sensors. Many successful pathogens have acquired sophisticated mechanisms to regulate the NF-κB signalling pathways by deploying subversive proteins or hijacking the host signalling molecules. Here, we describe the mechanisms by which viruses and bacteria micromanage the host NF-κB signalling circuitry to favour the continued survival of the pathogen.

Original languageEnglish (US)
Pages (from-to)291-306
Number of pages16
JournalNature Reviews Microbiology
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

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Proteins
Transcription Factors
Viruses
Bacteria
Infection

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Modulation of NF-κB signalling by microbial pathogens. / Rahman, Masmudur; McFadden, Douglas.

In: Nature Reviews Microbiology, Vol. 9, No. 4, 01.04.2011, p. 291-306.

Research output: Contribution to journalReview article

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