Modulation of extracellular neurotransmitter levels in the nucleus accumbens by a taurine uptake inhibitor

M. Foster Olive, Kristin K. Mehmert, Clyde W. Hodge

Research output: Contribution to journalArticle

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Abstract

Using in vivo microdialysis, we examined the effect of local perfusion of the taurine uptake inhibitor guanidinoethyl sulfonate on extracellular levels of various neurotransmitters in the rat nucleus accumbens. Guanidinoethyl sulfonate (500 μM-50 mM) produced a concentration-dependent increase in extracellular taurine levels. While 500 μM and 5 mM concentrations of guanidinoethyl sulfonate were largely without effect, 50 mM guanidinoethyl sulfonate produced a significant decrease in extracellular levels of aspartate, glutamate and glycine, with no effect on extracellular dopamine levels. These results indicate that guanidinoethyl sulfonate can modulate extracellular amino acid levels in the nucleus accumbens. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalEuropean Journal of Pharmacology
Volume409
Issue number3
DOIs
StatePublished - Dec 15 2000

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Keywords

  • (Rat)
  • Amino acid
  • Dopamine
  • Guanidinoethyl sulfonate
  • Microdialysis

ASJC Scopus subject areas

  • Pharmacology

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