Abstract
Using in vivo microdialysis, we examined the effect of local perfusion of the taurine uptake inhibitor guanidinoethyl sulfonate on extracellular levels of various neurotransmitters in the rat nucleus accumbens. Guanidinoethyl sulfonate (500 μM-50 mM) produced a concentration-dependent increase in extracellular taurine levels. While 500 μM and 5 mM concentrations of guanidinoethyl sulfonate were largely without effect, 50 mM guanidinoethyl sulfonate produced a significant decrease in extracellular levels of aspartate, glutamate and glycine, with no effect on extracellular dopamine levels. These results indicate that guanidinoethyl sulfonate can modulate extracellular amino acid levels in the nucleus accumbens. (C) 2000 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 291-294 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 409 |
Issue number | 3 |
DOIs | |
State | Published - Dec 15 2000 |
Externally published | Yes |
Keywords
- (Rat)
- Amino acid
- Dopamine
- Guanidinoethyl sulfonate
- Microdialysis
ASJC Scopus subject areas
- Pharmacology