Modification of bacterial serum susceptibility by rifampin

W. J. Alexander, C. G. Cobbs, R. Curtiss

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A subinhibitory concentration of rifampin converted a strain of Escherichia coli from serum resistant to serum susceptible. When continually cultured in nutrient broth containing 1.5 μg of rifampin per ml, this strain of E. coli became susceptible to killing by both normal human serum and normal rabbit serum. Compared to the original strain, the rifampin-treated E. coli displayed no detectable change in adherence capability, but appeared less virulent in the rabbit model of endocarditis. A rifampin-resistant mutant of the E. coli strain was not found to undergo conversion to serum susceptibility upon culture in rifampin.

Original languageEnglish (US)
Pages (from-to)923-926
Number of pages4
JournalInfection and immunity
Volume28
Issue number3
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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    Alexander, W. J., Cobbs, C. G., & Curtiss, R. (1980). Modification of bacterial serum susceptibility by rifampin. Infection and immunity, 28(3), 923-926.