Modification of bacterial serum susceptibility by rifampin

W. J. Alexander, C. G. Cobbs, R. Curtiss

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A subinhibitory concentration of rifampin converted a strain of Escherichia coli from serum resistant to serum susceptible. When continually cultured in nutrient broth containing 1.5 μg of rifampin per ml, this strain of E. coli became susceptible to killing by both normal human serum and normal rabbit serum. Compared to the original strain, the rifampin-treated E. coli displayed no detectable change in adherence capability, but appeared less virulent in the rabbit model of endocarditis. A rifampin-resistant mutant of the E. coli strain was not found to undergo conversion to serum susceptibility upon culture in rifampin.

Original languageEnglish (US)
Pages (from-to)923-926
Number of pages4
JournalInfection and Immunity
Volume28
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Rifampin
Escherichia coli
Serum
Rabbits
Endocarditis
Food

ASJC Scopus subject areas

  • Immunology

Cite this

Alexander, W. J., Cobbs, C. G., & Curtiss, R. (1980). Modification of bacterial serum susceptibility by rifampin. Infection and Immunity, 28(3), 923-926.

Modification of bacterial serum susceptibility by rifampin. / Alexander, W. J.; Cobbs, C. G.; Curtiss, R.

In: Infection and Immunity, Vol. 28, No. 3, 1980, p. 923-926.

Research output: Contribution to journalArticle

Alexander, WJ, Cobbs, CG & Curtiss, R 1980, 'Modification of bacterial serum susceptibility by rifampin', Infection and Immunity, vol. 28, no. 3, pp. 923-926.
Alexander WJ, Cobbs CG, Curtiss R. Modification of bacterial serum susceptibility by rifampin. Infection and Immunity. 1980;28(3):923-926.
Alexander, W. J. ; Cobbs, C. G. ; Curtiss, R. / Modification of bacterial serum susceptibility by rifampin. In: Infection and Immunity. 1980 ; Vol. 28, No. 3. pp. 923-926.
@article{ce54c40fb2254ada9999b03643486d5a,
title = "Modification of bacterial serum susceptibility by rifampin",
abstract = "A subinhibitory concentration of rifampin converted a strain of Escherichia coli from serum resistant to serum susceptible. When continually cultured in nutrient broth containing 1.5 μg of rifampin per ml, this strain of E. coli became susceptible to killing by both normal human serum and normal rabbit serum. Compared to the original strain, the rifampin-treated E. coli displayed no detectable change in adherence capability, but appeared less virulent in the rabbit model of endocarditis. A rifampin-resistant mutant of the E. coli strain was not found to undergo conversion to serum susceptibility upon culture in rifampin.",
author = "Alexander, {W. J.} and Cobbs, {C. G.} and R. Curtiss",
year = "1980",
language = "English (US)",
volume = "28",
pages = "923--926",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "3",

}

TY - JOUR

T1 - Modification of bacterial serum susceptibility by rifampin

AU - Alexander, W. J.

AU - Cobbs, C. G.

AU - Curtiss, R.

PY - 1980

Y1 - 1980

N2 - A subinhibitory concentration of rifampin converted a strain of Escherichia coli from serum resistant to serum susceptible. When continually cultured in nutrient broth containing 1.5 μg of rifampin per ml, this strain of E. coli became susceptible to killing by both normal human serum and normal rabbit serum. Compared to the original strain, the rifampin-treated E. coli displayed no detectable change in adherence capability, but appeared less virulent in the rabbit model of endocarditis. A rifampin-resistant mutant of the E. coli strain was not found to undergo conversion to serum susceptibility upon culture in rifampin.

AB - A subinhibitory concentration of rifampin converted a strain of Escherichia coli from serum resistant to serum susceptible. When continually cultured in nutrient broth containing 1.5 μg of rifampin per ml, this strain of E. coli became susceptible to killing by both normal human serum and normal rabbit serum. Compared to the original strain, the rifampin-treated E. coli displayed no detectable change in adherence capability, but appeared less virulent in the rabbit model of endocarditis. A rifampin-resistant mutant of the E. coli strain was not found to undergo conversion to serum susceptibility upon culture in rifampin.

UR - http://www.scopus.com/inward/record.url?scp=0018852486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018852486&partnerID=8YFLogxK

M3 - Article

C2 - 6995328

AN - SCOPUS:0018852486

VL - 28

SP - 923

EP - 926

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 3

ER -