TY - JOUR
T1 - Models of brainstem responses to bilateral electrical stimulation
AU - Colburn, H. Steven
AU - Chung, Yoojin
AU - Zhou, Yi
AU - Brughera, Andrew
N1 - Funding Information:
This work was supported by the US Public Health Service: NIH grants R01 DC05775 (B. Delgutte, PI) [supporting Chung, Colburn, and Zhou], R01 DC00100 (H.S. Colburn, PI) [supporting Brughera]. and P30 DC04663 (Core Center) [supporting model implementation in Earlab]. The authors gratefully acknowledge the careful reviews and good suggestions received from the Editors and three anonymous reviewers. With respect to the authors’ contributions, all authors contributed to experimental design, and to the evaluation and discussion of results; the model simulations of unmodulated and modulated stimuli were conducted by Brughera and Zhou, respectively.
PY - 2009/3
Y1 - 2009/3
N2 - A simple, biophysically specified cell model is used to predict responses of binaurally sensitive neurons to patterns of input spikes that represent stimulation by acoustic and electric waveforms. Specifically, the effects of changes in parameters of input spike trains on model responses to interaural time difference (ITD) were studied for low-frequency periodic stimuli, with or without amplitude modulation. Simulations were limited to purely excitatory, bilaterally driven cell models with basic ionic currents and multiple input fibers. Parameters explored include average firing rate, synchrony index, modulation frequency, and latency dispersion of the input trains as well as the excitatory conductance and time constant of individual synapses in the cell model. Results are compared to physiological recordings from the inferior colliculus (IC) and discussed in terms of ITD-discrimination abilities of listeners with cochlear implants. Several empirically observed aspects of ITD sensitivity were simulated without evoking complex neural processing. Specifically, our results show saturation effects in rate-ITD curves, the absence of sustained responses to high-rate unmodulated pulse trains, the renewal of sensitivity to ITD in high-rate trains when inputs are amplitude-modulated, and interactions between envelope and fine-structure delays for some modulation frequencies.
AB - A simple, biophysically specified cell model is used to predict responses of binaurally sensitive neurons to patterns of input spikes that represent stimulation by acoustic and electric waveforms. Specifically, the effects of changes in parameters of input spike trains on model responses to interaural time difference (ITD) were studied for low-frequency periodic stimuli, with or without amplitude modulation. Simulations were limited to purely excitatory, bilaterally driven cell models with basic ionic currents and multiple input fibers. Parameters explored include average firing rate, synchrony index, modulation frequency, and latency dispersion of the input trains as well as the excitatory conductance and time constant of individual synapses in the cell model. Results are compared to physiological recordings from the inferior colliculus (IC) and discussed in terms of ITD-discrimination abilities of listeners with cochlear implants. Several empirically observed aspects of ITD sensitivity were simulated without evoking complex neural processing. Specifically, our results show saturation effects in rate-ITD curves, the absence of sustained responses to high-rate unmodulated pulse trains, the renewal of sensitivity to ITD in high-rate trains when inputs are amplitude-modulated, and interactions between envelope and fine-structure delays for some modulation frequencies.
KW - Auditory brainstem model
KW - Binaural hearing
KW - Cochlear implant
KW - Electric hearing
KW - Interaural time delay
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U2 - 10.1007/s10162-008-0141-z
DO - 10.1007/s10162-008-0141-z
M3 - Article
C2 - 18941838
AN - SCOPUS:67349144048
SN - 1525-3961
VL - 10
SP - 91
EP - 110
JO - JARO - Journal of the Association for Research in Otolaryngology
JF - JARO - Journal of the Association for Research in Otolaryngology
IS - 1
ER -