Modelling the impact of antigen kinetics on T-cell activation and response

Dennis L. Chao, Miles P. Davenport, Stephanie Forrest, Alan S. Perelson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Cytotoxic T lymphocyte (CTL) responses are thought to be important for the control of many viral and other infections. Qualitative aspects of the CTL response, including the epitope specificity, affinity, and clonal composition, may affect the ability of T cells to mediate infection control. Although it is clear that the mode of introduction and the dose of antigen can affect these qualitative aspects of the response, little is understood of the mechanisms. We have developed an in silico model of the CTL response, which we use to study the impact of antigen dose, antigen kinetics and repeated antigen delivery on the response. The results suggest that recent observations on differences in response to killed antigen can be explained simply by differences in timing of T-cell activation. These findings may provide insight into how different vaccination strategies can quantitatively and qualitatively affect the outcome of the immune response.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalImmunology and Cell Biology
Volume82
Issue number1
DOIs
StatePublished - Feb 1 2004
Externally publishedYes

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Keywords

  • Antigen kinetics
  • Computer modelling
  • Cytotoxic T lymphocytes
  • T-cell activation
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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