Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy

Hang Xie, Yang Jiao, Qihui Fan, Miaomiao Hai, Jiaen Yang, Zhijian Hu, Yue Yang, Jianwei Shuai, Guo Chen, Ruchuan Liu, Liyu Liu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A systematic understanding of the evolution and growth dynamics of invasive solid tumors in response to different chemotherapy strategies is crucial for the development of individually optimized oncotherapy. Here, we develop a hybrid three-dimensional (3D) computational model that integrates pharmacokinetic model, continuum diffusion-reaction model and discrete cell automaton model to investigate 3D invasive solid tumor growth in heterogeneous microenvironment under chemotherapy. Specifically, we consider the effects of heterogeneous environment on drug diffusion, tumor growth, invasion and the drug-tumor interaction on individual cell level. We employ the hybrid model to investigate the evolution and growth dynamics of avascular invasive solid tumors under different chemotherapy strategies. Our simulations indicate that constant dosing is generally more effective in suppressing primary tumor growth than periodic dosing, due to the resulting continuous high drug concentration. In highly heterogeneous microenvironment, the malignancy of the tumor is significantly enhanced, leading to inefficiency of chemotherapies. The effects of geometrically-confined microenvironment and non-uniform drug dosing are also investigated. Our computational model, when supplemented with sufficient clinical data, could eventually lead to the development of efficient in silico tools for prognosis and treatment strategy optimization.

Original languageEnglish (US)
Article numbere0206292
JournalPLoS One
Volume13
Issue number10
DOIs
StatePublished - Oct 1 2018

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Chemotherapy
drug therapy
Tumors
Drug Therapy
neoplasms
Growth
Neoplasms
drugs
Pharmaceutical Preparations
Pharmacokinetics
Tumor Microenvironment
Drug Interactions
Computer Simulation
pharmacokinetics
prognosis
cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy. / Xie, Hang; Jiao, Yang; Fan, Qihui; Hai, Miaomiao; Yang, Jiaen; Hu, Zhijian; Yang, Yue; Shuai, Jianwei; Chen, Guo; Liu, Ruchuan; Liu, Liyu.

In: PLoS One, Vol. 13, No. 10, e0206292, 01.10.2018.

Research output: Contribution to journalArticle

Xie, H, Jiao, Y, Fan, Q, Hai, M, Yang, J, Hu, Z, Yang, Y, Shuai, J, Chen, G, Liu, R & Liu, L 2018, 'Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy', PLoS One, vol. 13, no. 10, e0206292. https://doi.org/10.1371/journal.pone.0206292
Xie, Hang ; Jiao, Yang ; Fan, Qihui ; Hai, Miaomiao ; Yang, Jiaen ; Hu, Zhijian ; Yang, Yue ; Shuai, Jianwei ; Chen, Guo ; Liu, Ruchuan ; Liu, Liyu. / Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy. In: PLoS One. 2018 ; Vol. 13, No. 10.
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