Modeling the effects of fluoxetine on food-reinforced behavior

Federico Sanabria, Jazmin I. Acosta, Peter R. Killeen, Janet Neisewander, Lewis A. Bizo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We propose a novel method to dissociate incentive motivation from memory and motor processes in instrumental performance. Components of a multiple fixed-ratio schedule of food reinforcement were adjusted to envelop the range of response requirements that maintained lever pressing by rats. We sought to manipulate motivation for food rewards with acute administrations of various doses (0-10 mg/kg) of fluoxetine, a 5-HT reuptake inhibitor that reduces food intake. A quantitative model of fixed-ratio performance derived from Killeen's (1994) Mathematical Principles of Reinforcement (MPR) provided an adequate account of data from individual rats. Decreases in response rate resulting from fluoxetine were reflected in changes in estimates of activation, indexed by MPR parameter a; estimates of working memory capacity and lever pressing duration were not systematically affected. These results support the use of MPR parameter a to index incentive motivation using multiple fixed-ratio schedules that are adjusted to individual performance.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalBehavioural Pharmacology
Volume19
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

Fluoxetine
Motivation
Food
Reinforcement Schedule
Reward
Short-Term Memory
Serotonin
Appointments and Schedules
Eating
Reinforcement (Psychology)

Keywords

  • Fixed-ratio schedule of reinforcement
  • Fluoxetine
  • Food
  • Incentive motivation
  • Lever pressing
  • Models
  • Rat
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Neuroscience(all)

Cite this

Modeling the effects of fluoxetine on food-reinforced behavior. / Sanabria, Federico; Acosta, Jazmin I.; Killeen, Peter R.; Neisewander, Janet; Bizo, Lewis A.

In: Behavioural Pharmacology, Vol. 19, No. 1, 02.2008, p. 61-70.

Research output: Contribution to journalArticle

Sanabria, Federico ; Acosta, Jazmin I. ; Killeen, Peter R. ; Neisewander, Janet ; Bizo, Lewis A. / Modeling the effects of fluoxetine on food-reinforced behavior. In: Behavioural Pharmacology. 2008 ; Vol. 19, No. 1. pp. 61-70.
@article{f50172add1264173bd74a1a599329f5e,
title = "Modeling the effects of fluoxetine on food-reinforced behavior",
abstract = "We propose a novel method to dissociate incentive motivation from memory and motor processes in instrumental performance. Components of a multiple fixed-ratio schedule of food reinforcement were adjusted to envelop the range of response requirements that maintained lever pressing by rats. We sought to manipulate motivation for food rewards with acute administrations of various doses (0-10 mg/kg) of fluoxetine, a 5-HT reuptake inhibitor that reduces food intake. A quantitative model of fixed-ratio performance derived from Killeen's (1994) Mathematical Principles of Reinforcement (MPR) provided an adequate account of data from individual rats. Decreases in response rate resulting from fluoxetine were reflected in changes in estimates of activation, indexed by MPR parameter a; estimates of working memory capacity and lever pressing duration were not systematically affected. These results support the use of MPR parameter a to index incentive motivation using multiple fixed-ratio schedules that are adjusted to individual performance.",
keywords = "Fixed-ratio schedule of reinforcement, Fluoxetine, Food, Incentive motivation, Lever pressing, Models, Rat, Serotonin",
author = "Federico Sanabria and Acosta, {Jazmin I.} and Killeen, {Peter R.} and Janet Neisewander and Bizo, {Lewis A.}",
year = "2008",
month = "2",
doi = "10.1097/FBP.0b013e3282f3df9b",
language = "English (US)",
volume = "19",
pages = "61--70",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Modeling the effects of fluoxetine on food-reinforced behavior

AU - Sanabria, Federico

AU - Acosta, Jazmin I.

AU - Killeen, Peter R.

AU - Neisewander, Janet

AU - Bizo, Lewis A.

PY - 2008/2

Y1 - 2008/2

N2 - We propose a novel method to dissociate incentive motivation from memory and motor processes in instrumental performance. Components of a multiple fixed-ratio schedule of food reinforcement were adjusted to envelop the range of response requirements that maintained lever pressing by rats. We sought to manipulate motivation for food rewards with acute administrations of various doses (0-10 mg/kg) of fluoxetine, a 5-HT reuptake inhibitor that reduces food intake. A quantitative model of fixed-ratio performance derived from Killeen's (1994) Mathematical Principles of Reinforcement (MPR) provided an adequate account of data from individual rats. Decreases in response rate resulting from fluoxetine were reflected in changes in estimates of activation, indexed by MPR parameter a; estimates of working memory capacity and lever pressing duration were not systematically affected. These results support the use of MPR parameter a to index incentive motivation using multiple fixed-ratio schedules that are adjusted to individual performance.

AB - We propose a novel method to dissociate incentive motivation from memory and motor processes in instrumental performance. Components of a multiple fixed-ratio schedule of food reinforcement were adjusted to envelop the range of response requirements that maintained lever pressing by rats. We sought to manipulate motivation for food rewards with acute administrations of various doses (0-10 mg/kg) of fluoxetine, a 5-HT reuptake inhibitor that reduces food intake. A quantitative model of fixed-ratio performance derived from Killeen's (1994) Mathematical Principles of Reinforcement (MPR) provided an adequate account of data from individual rats. Decreases in response rate resulting from fluoxetine were reflected in changes in estimates of activation, indexed by MPR parameter a; estimates of working memory capacity and lever pressing duration were not systematically affected. These results support the use of MPR parameter a to index incentive motivation using multiple fixed-ratio schedules that are adjusted to individual performance.

KW - Fixed-ratio schedule of reinforcement

KW - Fluoxetine

KW - Food

KW - Incentive motivation

KW - Lever pressing

KW - Models

KW - Rat

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=38149013802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149013802&partnerID=8YFLogxK

U2 - 10.1097/FBP.0b013e3282f3df9b

DO - 10.1097/FBP.0b013e3282f3df9b

M3 - Article

VL - 19

SP - 61

EP - 70

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 1

ER -