@inbook{963e1d8606a04b7084e2c10ba10e01af,
title = "Modeling ncRNA-mediated circuits in cell fate decision",
abstract = "Noncoding RNAs (ncRNAs) play critical roles in essential cell fate decisions. However, the exact molecular mechanisms underlying ncRNA-mediated bistable switches remain elusive and controversial. In recent years, systematic mathematical and quantitative experimental analyses have made significant contributions on elucidating the molecular mechanisms of controlling ncRNA-mediated cell fate decision processes. In this chapter, we review and summarize the general framework of mathematical modeling of ncRNA in a pedagogical way and the application of this general framework on real biological processes. We discuss the emerging properties resulting from the reciprocal regulation between mRNA, miRNA, and competing endogenous mRNA (ceRNA), as well as the role of mathematical modeling of ncRNA in synthetic biology. Both the positive feedback loops between ncRNAs and transcription factors and the emerging properties from the miRNA-mRNA reciprocal regulation enable bistable switches to direct cell fate decision.",
keywords = "Bistability, Cell fate decision, Competing endogenous mRNA, Mathematical modeling, Posttranscriptional, Ultrasensitivity",
author = "Tian, {Xiao Jun} and Ferro, {Manuela Vanegas} and Hanah Goetz",
note = "Funding Information: H.G. was supported by the Arizona State University Dean{\textquoteright}s Fellowship and M.V.F. was supported by Arizona State University Biological Design Program. This study was financially supported by the ASU School of Biological and Health Systems Engineering (X-J.T.). We apologize to the authors whose work could not be cited due to space constraints. Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2019.",
year = "2019",
doi = "10.1007/978-1-4939-8982-9_16",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "411--426",
booktitle = "Methods in Molecular Biology",
}