Model for a thermoelectric enzyme glucose sensor

M. J. Muehlbauer, E. J. Guilbeau, B. C. Towe

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A new calorimetric sensor that detects glucose through the change in enthalpy produced by an enzymatic reaction mathematically modeled. The sensor is a thermopile attached to a membrane of immobilized glucose oxidase and catalase enzymes. The model predicts the temperature rise that occurs within the membrane in response to the concentration of glucose. The dependence of the modeled temperature rise on various conditions such as the oxygen concentration, external heat and mass transfer, and enzyme loading is supported with experimental data from a prototype sensor. The sensitivity of the sensor to glucose is characterized in terms of two quantities: its initial value at low concentrations of glucose; and the range of response, specified as the concentration of glucose at which the sensitivity deviates from its initial value by 10%.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalAnalytical Chemistry
Volume61
Issue number1
StatePublished - Jan 1 1989

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Enzyme sensors
Glucose sensors
Glucose
Sensors
Thermopiles
Membranes
Glucose Oxidase
Enzymes
Catalase
Enthalpy
Mass transfer
Oxygen
Heat transfer
Temperature

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Muehlbauer, M. J., Guilbeau, E. J., & Towe, B. C. (1989). Model for a thermoelectric enzyme glucose sensor. Analytical Chemistry, 61(1), 77-83.

Model for a thermoelectric enzyme glucose sensor. / Muehlbauer, M. J.; Guilbeau, E. J.; Towe, B. C.

In: Analytical Chemistry, Vol. 61, No. 1, 01.01.1989, p. 77-83.

Research output: Contribution to journalArticle

Muehlbauer, MJ, Guilbeau, EJ & Towe, BC 1989, 'Model for a thermoelectric enzyme glucose sensor', Analytical Chemistry, vol. 61, no. 1, pp. 77-83.
Muehlbauer MJ, Guilbeau EJ, Towe BC. Model for a thermoelectric enzyme glucose sensor. Analytical Chemistry. 1989 Jan 1;61(1):77-83.
Muehlbauer, M. J. ; Guilbeau, E. J. ; Towe, B. C. / Model for a thermoelectric enzyme glucose sensor. In: Analytical Chemistry. 1989 ; Vol. 61, No. 1. pp. 77-83.
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