Mixture and mixture-process variable experiments for pharmaceutical applications

Christine M. Anderson-Cook, Heidi B. Goldfarb, Connie M. Borror, Douglas Montgomery, Kelly G. Canter, John N. Twist

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Many experiments in research and development in the pharmaceutical industry involve mixture components. These are experiments in which the experimental factors are the ingredients of a mixture and the response variable is a function of the relative proportion of each ingredient, not its absolute amount. Thus the mixture ingredients cannot be varied independently. A common variation of the mixture experiment occurs when there are also one or more process factors that can be varied independently of each other and of the mixture components, leading to a mixture-process variable experiment. We discuss the design and analysis of these types of experiments, using tablet formulation as an example. Our objective is to encourage greater utilization of these techniques in pharmaceutical research and development.

Original languageEnglish (US)
Pages (from-to)247-260
Number of pages14
JournalPharmaceutical Statistics
Volume3
Issue number4
DOIs
StatePublished - Oct 2004

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Pharmaceuticals
Drug Industry
Research
Pharmaceutical Preparations
Tablets
Experiment
Research and Development
Mixture Experiments
Proportion
Industry
Formulation
Pharmaceutical Research

Keywords

  • Analysis of variance
  • Design of experiments
  • Mixture experiments
  • Response surface methodology
  • Scheffe model
  • Unconstrained and constrained regions

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Statistics and Probability

Cite this

Anderson-Cook, C. M., Goldfarb, H. B., Borror, C. M., Montgomery, D., Canter, K. G., & Twist, J. N. (2004). Mixture and mixture-process variable experiments for pharmaceutical applications. Pharmaceutical Statistics, 3(4), 247-260. https://doi.org/10.1002/pst.138

Mixture and mixture-process variable experiments for pharmaceutical applications. / Anderson-Cook, Christine M.; Goldfarb, Heidi B.; Borror, Connie M.; Montgomery, Douglas; Canter, Kelly G.; Twist, John N.

In: Pharmaceutical Statistics, Vol. 3, No. 4, 10.2004, p. 247-260.

Research output: Contribution to journalArticle

Anderson-Cook, CM, Goldfarb, HB, Borror, CM, Montgomery, D, Canter, KG & Twist, JN 2004, 'Mixture and mixture-process variable experiments for pharmaceutical applications', Pharmaceutical Statistics, vol. 3, no. 4, pp. 247-260. https://doi.org/10.1002/pst.138
Anderson-Cook, Christine M. ; Goldfarb, Heidi B. ; Borror, Connie M. ; Montgomery, Douglas ; Canter, Kelly G. ; Twist, John N. / Mixture and mixture-process variable experiments for pharmaceutical applications. In: Pharmaceutical Statistics. 2004 ; Vol. 3, No. 4. pp. 247-260.
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