Mitochondrial DNA integrity changes with age but does not correlate with learning performance in honey bees

E. M. Hystad, Gro Amdam, L. Eide

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The honey bee is a well-established model organism to study aging, learning and memory. Here, we used young and old forager honey bees to investigate whether age-related learning capacity correlates with mitochondrial function. The bees were selected for age and learning performance and mitochondrial function was evaluated by measuring mtDNA integrity, mtDNA copy number and mitochondrial gene expression. Quite unexpectedly, mtDNA from young bees showed more damage than mtDNA from older bees, but neither mtDNA integrity, nor mtDNA copy number nor mitochondrial gene expression correlated with learning performance. Although not statistically significant ( p= 0.07) the level of L-rRNA increased with age in good learners whereas it decreased in poor learners. Our results show that learning performance in honey bee does not correlate with absolute mitochondrial parameters like mtDNA damage, copy number or expression of mitochondrial genes, but may be associated with the ability to regulate mitochondrial activity.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalExperimental Gerontology
Volume49
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Honey
Bees
Mitochondrial DNA
Learning
Mitochondrial Genes
Gene expression
Gene Expression
Aptitude
Genes
Aging of materials
Data storage equipment

Keywords

  • Aging
  • DNA damage
  • Honey bee
  • Learning
  • MtDNA
  • RRNA

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

Mitochondrial DNA integrity changes with age but does not correlate with learning performance in honey bees. / Hystad, E. M.; Amdam, Gro; Eide, L.

In: Experimental Gerontology, Vol. 49, No. 1, 01.2014, p. 12-18.

Research output: Contribution to journalArticle

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