Mitochondrial DNA and the peopling of South America

Cecil M. Lewis, Beatriz Lizárraga, Raúl Y. Tito, Paul W. López, Gian Carlo Iannacone, Angel Medina, Rolando Martínez, Susan I. Polo, Augusto F. De La Cruz, Angela M. Cáceres, Anne Stone

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The initial peopling of South America is largely unresolved, in part because of the unique distribution of genetic diversity in native South Americans. On average, genetic diversity estimated within Andean populations is higher than that estimated within Amazonian populations. Yet there is less genetic differentiation estimated among Andean populations than estimated among Amazonian populations. One hypothesis is that this pattern is a product of independent migrations of genetically differentiated people into South America. A competing hypothesis is that there was a single migration followed by regional isolation. In this study we address these hypotheses using mtDNA hypervariable region 1 sequences representing 21 South American groups and include new data sets for four native Peruvian communities from Tupe, Yungay, and Puno. An analysis of variance that compared the combined data from western South America to the combined data from eastern South America determined that these two regional data sets are not significantly different. As a result, a migration from a single source population into South America serves as the simplest explanation of the data.

Original languageEnglish (US)
Pages (from-to)159-178
Number of pages20
JournalHuman Biology
Volume79
Issue number2
StatePublished - Apr 2007

Fingerprint

South America
Mitochondrial DNA
mitochondrial DNA
Population
genetic variation
North American Indians
genetic differentiation
variance analysis
Analysis of Variance
analysis of variance
Datasets
genetic diversity

Keywords

  • Amazonian populations
  • Amerindians
  • Amova
  • Andean populations
  • Hypervariable region 1
  • MTDNA
  • Native Americans
  • Peopling of South America
  • Peru

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Lewis, C. M., Lizárraga, B., Tito, R. Y., López, P. W., Iannacone, G. C., Medina, A., ... Stone, A. (2007). Mitochondrial DNA and the peopling of South America. Human Biology, 79(2), 159-178.

Mitochondrial DNA and the peopling of South America. / Lewis, Cecil M.; Lizárraga, Beatriz; Tito, Raúl Y.; López, Paul W.; Iannacone, Gian Carlo; Medina, Angel; Martínez, Rolando; Polo, Susan I.; De La Cruz, Augusto F.; Cáceres, Angela M.; Stone, Anne.

In: Human Biology, Vol. 79, No. 2, 04.2007, p. 159-178.

Research output: Contribution to journalArticle

Lewis, CM, Lizárraga, B, Tito, RY, López, PW, Iannacone, GC, Medina, A, Martínez, R, Polo, SI, De La Cruz, AF, Cáceres, AM & Stone, A 2007, 'Mitochondrial DNA and the peopling of South America', Human Biology, vol. 79, no. 2, pp. 159-178.
Lewis CM, Lizárraga B, Tito RY, López PW, Iannacone GC, Medina A et al. Mitochondrial DNA and the peopling of South America. Human Biology. 2007 Apr;79(2):159-178.
Lewis, Cecil M. ; Lizárraga, Beatriz ; Tito, Raúl Y. ; López, Paul W. ; Iannacone, Gian Carlo ; Medina, Angel ; Martínez, Rolando ; Polo, Susan I. ; De La Cruz, Augusto F. ; Cáceres, Angela M. ; Stone, Anne. / Mitochondrial DNA and the peopling of South America. In: Human Biology. 2007 ; Vol. 79, No. 2. pp. 159-178.
@article{a91d56c7510449648c49c4788878fdc0,
title = "Mitochondrial DNA and the peopling of South America",
abstract = "The initial peopling of South America is largely unresolved, in part because of the unique distribution of genetic diversity in native South Americans. On average, genetic diversity estimated within Andean populations is higher than that estimated within Amazonian populations. Yet there is less genetic differentiation estimated among Andean populations than estimated among Amazonian populations. One hypothesis is that this pattern is a product of independent migrations of genetically differentiated people into South America. A competing hypothesis is that there was a single migration followed by regional isolation. In this study we address these hypotheses using mtDNA hypervariable region 1 sequences representing 21 South American groups and include new data sets for four native Peruvian communities from Tupe, Yungay, and Puno. An analysis of variance that compared the combined data from western South America to the combined data from eastern South America determined that these two regional data sets are not significantly different. As a result, a migration from a single source population into South America serves as the simplest explanation of the data.",
keywords = "Amazonian populations, Amerindians, Amova, Andean populations, Hypervariable region 1, MTDNA, Native Americans, Peopling of South America, Peru",
author = "Lewis, {Cecil M.} and Beatriz Liz{\'a}rraga and Tito, {Ra{\'u}l Y.} and L{\'o}pez, {Paul W.} and Iannacone, {Gian Carlo} and Angel Medina and Rolando Mart{\'i}nez and Polo, {Susan I.} and {De La Cruz}, {Augusto F.} and C{\'a}ceres, {Angela M.} and Anne Stone",
year = "2007",
month = "4",
language = "English (US)",
volume = "79",
pages = "159--178",
journal = "Human Biology",
issn = "0018-7143",
publisher = "Wayne State University Press",
number = "2",

}

TY - JOUR

T1 - Mitochondrial DNA and the peopling of South America

AU - Lewis, Cecil M.

AU - Lizárraga, Beatriz

AU - Tito, Raúl Y.

AU - López, Paul W.

AU - Iannacone, Gian Carlo

AU - Medina, Angel

AU - Martínez, Rolando

AU - Polo, Susan I.

AU - De La Cruz, Augusto F.

AU - Cáceres, Angela M.

AU - Stone, Anne

PY - 2007/4

Y1 - 2007/4

N2 - The initial peopling of South America is largely unresolved, in part because of the unique distribution of genetic diversity in native South Americans. On average, genetic diversity estimated within Andean populations is higher than that estimated within Amazonian populations. Yet there is less genetic differentiation estimated among Andean populations than estimated among Amazonian populations. One hypothesis is that this pattern is a product of independent migrations of genetically differentiated people into South America. A competing hypothesis is that there was a single migration followed by regional isolation. In this study we address these hypotheses using mtDNA hypervariable region 1 sequences representing 21 South American groups and include new data sets for four native Peruvian communities from Tupe, Yungay, and Puno. An analysis of variance that compared the combined data from western South America to the combined data from eastern South America determined that these two regional data sets are not significantly different. As a result, a migration from a single source population into South America serves as the simplest explanation of the data.

AB - The initial peopling of South America is largely unresolved, in part because of the unique distribution of genetic diversity in native South Americans. On average, genetic diversity estimated within Andean populations is higher than that estimated within Amazonian populations. Yet there is less genetic differentiation estimated among Andean populations than estimated among Amazonian populations. One hypothesis is that this pattern is a product of independent migrations of genetically differentiated people into South America. A competing hypothesis is that there was a single migration followed by regional isolation. In this study we address these hypotheses using mtDNA hypervariable region 1 sequences representing 21 South American groups and include new data sets for four native Peruvian communities from Tupe, Yungay, and Puno. An analysis of variance that compared the combined data from western South America to the combined data from eastern South America determined that these two regional data sets are not significantly different. As a result, a migration from a single source population into South America serves as the simplest explanation of the data.

KW - Amazonian populations

KW - Amerindians

KW - Amova

KW - Andean populations

KW - Hypervariable region 1

KW - MTDNA

KW - Native Americans

KW - Peopling of South America

KW - Peru

UR - http://www.scopus.com/inward/record.url?scp=35448990958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35448990958&partnerID=8YFLogxK

M3 - Article

C2 - 18027812

AN - SCOPUS:35448990958

VL - 79

SP - 159

EP - 178

JO - Human Biology

JF - Human Biology

SN - 0018-7143

IS - 2

ER -