TY - GEN
T1 - Miniaturized Passive Bio-mechanical Valve for Hydrocephalus Treatment
AU - Jung, Yuna
AU - Gulick, Daniel
AU - Christen, Jennifer Blain
N1 - Funding Information:
Research reported in this publication was supported by DOD-ARMY: Army Medical Research Acquisition Activity (USAMRAA) under a CDMRP (Congressionally Directed Medical Research Program) grant W81XWH2010805, “A Miniaturized Valve that Mimics Functional Arachnoid Granulations to Treat Hydrocephalus”. The authors would like to acknowledge Prof. Junseok Chae, Dr. Ruth E. Bristol and Dr. Mark C. Preul for their assistance on the research Fig. 1. Illustration of HCP treatment methods. (a) Depiction of the most commonly implanted shunt system composed of two catheters (proximal and distal) and a valve adapted from [6] (b) Miniaturized valve placed within the intracranial space to drain CSF from SAS to SSS.
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Hydrocephalus is an accumulation of excess pressure in the brain due to malfunction of the fluid drainage system, arachnoid granulations. Standard treatment uses a shunt to drain excess cerebrospinal fluid to the abdomen. Conventional shunts suffer high failure rates over time. To reduce failure, we propose replacing the shunt with a miniaturized valve placed in the intracranial space. Our current prototype uses a duckbill valve design with 1 mm outlet width. The valve leaflets are silicone (PDMS), with the fluid channel defined using photolithography. In bench top pressure vs. flow testing, the silicone duckbill valve achieved the target cracking pressure range of 5 to 15 cmH2O with no cycling degradation or reverse flow leakage. Upcoming studies will monitor long-term degradation and test valve performance in vivo.
AB - Hydrocephalus is an accumulation of excess pressure in the brain due to malfunction of the fluid drainage system, arachnoid granulations. Standard treatment uses a shunt to drain excess cerebrospinal fluid to the abdomen. Conventional shunts suffer high failure rates over time. To reduce failure, we propose replacing the shunt with a miniaturized valve placed in the intracranial space. Our current prototype uses a duckbill valve design with 1 mm outlet width. The valve leaflets are silicone (PDMS), with the fluid channel defined using photolithography. In bench top pressure vs. flow testing, the silicone duckbill valve achieved the target cracking pressure range of 5 to 15 cmH2O with no cycling degradation or reverse flow leakage. Upcoming studies will monitor long-term degradation and test valve performance in vivo.
KW - Miniaturization
KW - implantable valve
KW - pressure-flow measurement
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U2 - 10.1109/SENSORS52175.2022.9967194
DO - 10.1109/SENSORS52175.2022.9967194
M3 - Conference contribution
AN - SCOPUS:85144023145
T3 - Proceedings of IEEE Sensors
BT - 2022 IEEE Sensors, SENSORS 2022 - Conference Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2022 IEEE Sensors Conference, SENSORS 2022
Y2 - 30 October 2022 through 2 November 2022
ER -