Milk bioactives maymanipulate microbes tomediate parent-offspring conflict

Cary R. Allen-Blevins, David A. Sela, Katie Hinde

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Among mammals, milk constituents directly influence the ecology of the infant's commensal microbiota.The immunological and nutritional impacts of breast milk and microbiota are increasingly wellunderstood; less clear are the consequences for infant behavior. Here, we propose that interactionsamong bioactives in mother's milk and microbes in the infant gut contribute to infant behavioralphenotype and, in part, have the potential to mediate parent-offspring conflict. We hypothesize thatinfant behavior likely varies as a function of their mother's milk composition interacting with the infant'sneurobiology directly and indirectly through the commensal gut bacteria. In this article, we will exploreour hypothesis of a milk-microbiota-brain-behavior dynamic in the context of the coevolution betweenhuman milk oligosaccharides, bacteria, the gut-brain axis and behavior. Integrating established featuresof these systems allows us to generate novel hypotheses to motivate future research and considerpotential implications of current and emerging clinical treatments.

Original languageEnglish (US)
Article numbereov007
Pages (from-to)106-121
Number of pages16
JournalEvolution, Medicine and Public Health
Volume2015
Issue number1
DOIs
StatePublished - 2015

Keywords

  • Commensal bacteria
  • Human milk oligosaccharides
  • Infant development
  • Lactation
  • Maternal investment
  • Microbiota

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Health, Toxicology and Mutagenesis

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