Microscale transport physics during atomic force microscopy mass spectrometry and improved sampling efficiency

Hyunkyu Moon, Troy J. Comi, Sage J.B. Dunham, Beomjin Kwon, Jonathan V. Sweedler, William P. King

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports improvements of atomic force microscopy (AFM) mass spectrometry (MS), in which ∼1 attoliter of analyte is desorbed by a heated AFM cantilever tip and analyzed with a mass spectrometer. Decoupling the AFM sampling apparatus from the MS system enabled analysis of the microscale transport physics independent of analyte ionization efficiency. Using this approach, we find that the transport efficiency is governed by the air velocity during sampling, and not mass flow rate as reported in the literature. We also find that an unheated sampling tube results in higher efficiency compared to a heated tube. Optimization of the transport parameters improved the system efficiency by 2.5-fold over the state of the art.

Original languageEnglish (US)
Title of host publicationTRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages24-27
Number of pages4
ISBN (Electronic)9781538627310
DOIs
StatePublished - Jul 26 2017
Externally publishedYes
Event19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017 - Kaohsiung, Taiwan, Province of China
Duration: Jun 18 2017Jun 22 2017

Publication series

NameTRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems

Conference

Conference19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017
Country/TerritoryTaiwan, Province of China
CityKaohsiung
Period6/18/176/22/17

Keywords

  • Atomic force microscopy
  • heated cantilever
  • mass spectrometry
  • thermal desorption
  • transport physics

ASJC Scopus subject areas

  • Chemical Health and Safety
  • Instrumentation
  • Electrical and Electronic Engineering

Fingerprint

Dive into the research topics of 'Microscale transport physics during atomic force microscopy mass spectrometry and improved sampling efficiency'. Together they form a unique fingerprint.

Cite this