TY - GEN
T1 - Micropattern effect on breast cancer cells behavior on isotropically etched silicon microenvironments
AU - Nikkhah, Mehdi
AU - Strobl, Jeannine S.
AU - Peddi, Bhanu
AU - Omotosho, Adedamola
AU - Agah, Masoud
PY - 2010/1/1
Y1 - 2010/1/1
N2 - In this paper we are investigating three dimensional (3-D) silicon-based microenvironments as potential platforms for breast cancer diagnostics. We have developed isotropically etched microstructures with a wide range of geometrical patterns for this purpose. Our results indicate that with the etched surface ratio of ∼65%, it is possible to capture 80-90% of the cancer cells within each silicon chip. After treatment of the cells with mitomycin C (to block the cell growth) more number of the cells are trapped inside the etched features for longer cultures times (72 h) suggesting that there is a directed motility and attraction of the cells toward the etched cavities and by optimally designing the etched features, the proposed platforms can be potentially used for diagnostics purposes.
AB - In this paper we are investigating three dimensional (3-D) silicon-based microenvironments as potential platforms for breast cancer diagnostics. We have developed isotropically etched microstructures with a wide range of geometrical patterns for this purpose. Our results indicate that with the etched surface ratio of ∼65%, it is possible to capture 80-90% of the cancer cells within each silicon chip. After treatment of the cells with mitomycin C (to block the cell growth) more number of the cells are trapped inside the etched features for longer cultures times (72 h) suggesting that there is a directed motility and attraction of the cells toward the etched cavities and by optimally designing the etched features, the proposed platforms can be potentially used for diagnostics purposes.
UR - http://www.scopus.com/inward/record.url?scp=77955060378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955060378&partnerID=8YFLogxK
U2 - 10.1115/nemb2010-13030
DO - 10.1115/nemb2010-13030
M3 - Conference contribution
AN - SCOPUS:77955060378
SN - 9780791843925
T3 - Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
SP - 115
EP - 116
BT - Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
PB - ASME
T2 - 1st Global Congress on NanoEngineering for Medicine and Biology: Advancing Health Care through NanoEngineering and Computing, NEMB 2010
Y2 - 7 February 2010 through 10 February 2010
ER -