MicroED for the study of protein–ligand interactions and the potential for drug discovery

Lisa J. Clark, Guanhong Bu, Brent L. Nannenga, Tamir Gonen

Research output: Contribution to journalReview articlepeer-review

Abstract

Microcrystal electron diffraction (MicroED) is an electron cryo-microscopy (cryo-EM) technique used to determine molecular structures with crystals that are a millionth the size needed for traditional single-crystal X-ray crystallography. An exciting use of MicroED is in drug discovery and development, where it can be applied to the study of proteins and small molecule interactions, and for structure determination of natural products. The structures are then used for rational drug design and optimization. In this Perspective, we discuss the current applications of MicroED for structure determination of protein–ligand complexes and potential future applications in drug discovery. [Figure not available: see fulltext.]

Original languageEnglish (US)
JournalNature Reviews Chemistry
DOIs
StateAccepted/In press - 2021

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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