MicroED: A versatile cryoEM method for structure determination

Brent L. Nannenga, Tamir Gonen

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Micro-electron diffraction, or MicroED, is a structure determination method that uses a cryo-transmission electron microscope to collect electron diffraction data from nanocrystals. This technique has been successfully used to determine the high-resolution structures of many targets from crystals orders of magnitude smaller than what is needed for X-ray diffraction experiments. In this review, we will describe the MicroED method and recent structures that have been determined. Additionally, applications of electron diffraction to the fields of small molecule crystallography and materials science will be discussed.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalEmerging topics in life sciences
Volume2
Issue number1
DOIs
StatePublished - Apr 2018

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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