Microbiology of the Built Environment in Spacecraft Used for Human Flight

Jiseon Yang, Starla G. Thornhill, Jennifer Barrila, Cheryl Nickerson, C. Mark Ott, Robert J.C. McLean

Research output: Contribution to journalArticle

Abstract

Spacecraft, associated with human spaceflight, is one of the more unusual microbial environments. In contrast to other terrestrial environments, microorganisms within spacecraft are completely isolated from the rest of the biosphere and experience greatly reduced gravity (microgravity) and increased exposure to solar radiation. Microorganisms are introduced to this environment primarily through the microbiomes associated with spacecrew, as well as small numbers of microorganisms inadvertently introduced with supplies and equipment. In short-term studies (< 96 h) conducted during spaceflight, microgravity has been shown to influence the physiology and gene expression of several microorganisms. These studies can be modelled and extended on Earth using modelled microgravity (MMG) devices. Initial MMG studies, using microbial evolution approaches, show the potential for some microorganisms to develop altered phenotypes in response to microgravity, which in some instances persist during their return to full gravity (1 g) conditions. Extended space missions beyond low Earth orbit must consider microbial changes to virulence and antibiotic susceptibility in the context of microgravity-induced changes in the immune responses of spacecrew. As well microbial interactions with structural materials and life support functions must also be considered. In this chapter, we review current literature, focusing on studies conducted with the International Space Station.

Original languageEnglish (US)
JournalMethods in Microbiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Spacecraft
Weightlessness
Microbiology
Space Flight
Hypogravity
Microbial Interactions
Equipment and Supplies
Microbiota
Gravitation
Orbit
Virulence
Radiation
Anti-Bacterial Agents
Phenotype
Gene Expression

Keywords

  • Biofilm
  • Evolution
  • Low shear
  • Microbial
  • Microgravity
  • Spaceflight
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Microbiology of the Built Environment in Spacecraft Used for Human Flight. / Yang, Jiseon; Thornhill, Starla G.; Barrila, Jennifer; Nickerson, Cheryl; Ott, C. Mark; McLean, Robert J.C.

In: Methods in Microbiology, 01.01.2018.

Research output: Contribution to journalArticle

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