Microactuated Neural Probes to Compensate for Brain Micromotion

Jitendran Muthuswamy, A. Gilletti, T. Jain, M. Okandan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

One of the dominant failure modes of chronic neural implants is micromotion of the surrounding brain tissue relative to the implant leading to neuronal drift and shear injury. In this study, we have (a). Assessed the micromotion in the somatosensory cortex and (b). Designed, developed and tested a microactuated neural probe that can compensate for brain micromotion. We used a differential variable reluctance (DVRT) transducer in adult rats (n=8) to monitor micromotion in the somatosensory cortex. Electrostatic microactuators were fabricated using the SUMMIT (Sandia's Ultraplanar Multilevel MEMS Technology) process, a 5-layer polysilicon micro machining technology of the Sandia National labs, NM. In anesthetized rats, surface micromotion was observed to be in the order of 2-25 μm due to pressure changes during respiration and 1-3 μm due to vascular pulsatility. In addition there were long-term drifts in the order of 80 μm due to changes in the anesthetic level. The microactuated neural probe was capable of moving in steps of 1 μm with an aggregate translational capability in the order of several millimeters. In conclusion, there is significant micromotion in the surface of the somatosensory cortex that could lead to failure of chronic neural implants. Microactuated neural probes are capable of compensating for this micromotion.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages1941-1943
Number of pages3
Volume2
StatePublished - 2003
EventA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Other

OtherA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryMexico
CityCancun
Period9/17/039/21/03

Keywords

  • Chronic implants
  • Microelectrodes
  • Neural prostheses

ASJC Scopus subject areas

  • Bioengineering

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    Muthuswamy, J., Gilletti, A., Jain, T., & Okandan, M. (2003). Microactuated Neural Probes to Compensate for Brain Micromotion. In R. S. Leder (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 1941-1943)