MHC variation and tissue transplantation in fish

T. N. Cardwell, R. J. Sheffer, P. W. Hedrick

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Major histocompatibility complex (MHC) genes were originally discovered because of their role in tissue rejection in mammals and have subsequently been implicated in the incidence of autoimmune diseases and resistance to infectious diseases. Here we present the first demonstration that a gene defined by molecular sequence in the fish MHC, specifically a class II locus, plays an important role in tissue rejection. This effect in the endangered Gila topminnows appears to be additive and depends on the number of MHC alleles shared between the host and the recipient fish of the scale transplants. In addition, there was lower success of scale transplants in MHC-matched individuals in a population with high microsatellite variation than in a population with low variation. This suggests that other loci, presumably other MHC loci, play a significant role in transplantation success in fishes, as they do in mammals.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalJournal of Heredity
Volume92
Issue number4
StatePublished - 2001

Fingerprint

tissue transplantation
Tissue Transplantation
major histocompatibility complex
Major Histocompatibility Complex
Fishes
fish
loci
Mammals
Fundulidae
mammals
Transplants
Disease Resistance
autoimmune diseases
Microsatellite Repeats
Population
infectious diseases
Genes
Autoimmune Diseases
Communicable Diseases
genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Cardwell, T. N., Sheffer, R. J., & Hedrick, P. W. (2001). MHC variation and tissue transplantation in fish. Journal of Heredity, 92(4), 305-308.

MHC variation and tissue transplantation in fish. / Cardwell, T. N.; Sheffer, R. J.; Hedrick, P. W.

In: Journal of Heredity, Vol. 92, No. 4, 2001, p. 305-308.

Research output: Contribution to journalArticle

Cardwell, TN, Sheffer, RJ & Hedrick, PW 2001, 'MHC variation and tissue transplantation in fish', Journal of Heredity, vol. 92, no. 4, pp. 305-308.
Cardwell TN, Sheffer RJ, Hedrick PW. MHC variation and tissue transplantation in fish. Journal of Heredity. 2001;92(4):305-308.
Cardwell, T. N. ; Sheffer, R. J. ; Hedrick, P. W. / MHC variation and tissue transplantation in fish. In: Journal of Heredity. 2001 ; Vol. 92, No. 4. pp. 305-308.
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